CAJ | 학술논문

目的：探讨高压氧对兔耳增生性瘢痕后期转归的影响。方法：选取20只新西兰大耳白兔建立兔耳瘢痕模型，随机分成四组（A组、B组、C组和D组），每组5只。实验组（A～C ）造模4周后接受高压氧治疗，对照组（D ）处于常压环境。检测瘢痕形态学变化和瘢痕增生指数。结果：HE染色结果显示，与对照组相比，实验组胶原纤维增生减轻，毛细血管内皮增生明显；实验组瘢痕增生指数明显低于对照组（P＜0．05），瘢痕增生指数随高压氧疗程的增加而减小（P＜0．05）。结论：高压氧能够促进增生性瘢痕后期的消退。
목적：탐토고압양대토이증생성반흔후기전귀적영향。방법：선취20지신서란대이백토건립토이반흔모형，수궤분성사조（A조、B조、C조화D조），매조5지。실험조（A～C ）조모4주후접수고압양치료，대조조（D ）처우상압배경。검측반흔형태학변화화반흔증생지수。결과：HE염색결과현시，여대조조상비，실험조효원섬유증생감경，모세혈관내피증생명현；실험조반흔증생지수명현저우대조조（P＜0．05），반흔증생지수수고압양료정적증가이감소（P＜0．05）。결론：고압양능구촉진증생성반흔후기적소퇴。
Objective :To investigate the role of hyperbaric oxygen on the late hyperplastic scar of rabbit ears .Methods :20 New Zealand rabbits were used for hypertrophic scar model on the ears .The rabbits were randomly divided into 4 groups(A ,B ,C and D groups) ,5 in each group .The experiment groups (A ,B and C) were treated with hyperbaric oxy‐gen for 4 weeks after modeling ,while the control group (D) was kept in atmospheric environment .The morphological changes and hyperplastic of scars were assessed .Results:Compared with the control group ,collagen fiber hyperplasia was reduced ,while capillary endothelial hyperplasia was increased in the experiment groups by HE staining .Scar hy‐perplastic index in the experimental groups was significantly lower than that in the control group (P<0 .05) .Scar hy‐perplastic index was decreased with the increase of treatment significantly (P<0 .05) .Conclusion:Hyperbaric oxygen can repair hyperplastic scar at the late stage .