CAJ | 학술논문

临床上脂肪乳除了提供人体营养和能量外，其在非营养作用方面研究越来越多。脂肪乳对布比卡因等脂溶性药物中毒导致的心功能抑制具有解毒功能，这种机制存在脂质沉积、激活电压开放的钙通道等多种理论支持。另外，脂肪乳还有减轻缺血／再灌注损伤、减少炎性因子产生、辅助治疗急性呼吸窘迫综合征、抑制自然杀伤细胞活性和抑制肿瘤生长等多种非营养作用。
림상상지방유제료제공인체영양화능량외，기재비영양작용방면연구월래월다。지방유대포비잡인등지용성약물중독도치적심공능억제구유해독공능，저충궤제존재지질침적、격활전압개방적개통도등다충이론지지。령외，지방유환유감경결혈／재관주손상、감소염성인자산생、보조치료급성호흡군박종합정、억제자연살상세포활성화억제종류생장등다충비영양작용。
The main functions of lipid emulsion are to provide nutrition and energy .There are more and more researches about its non-nutritional functions.Lipid emulsion can reduce the inhibition of cardiac func-tion,which is the result of the toxicity of overdose of lipophilic drugs like bupivacaine.The mechanism is supported by lipid sink and other theories such as activating voltage opening of the calcium channels .Furthe-more,lipid emulsion can also reduce ischemia-reperfusion injury,decrease inflammatory cytokines,help to treat acute respiratory distress syndrome,suppress activity of natural killer cell and suppress tumor growth.