中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2015年
3期
225-227
,共3页
刘平%张宝和%连士杰%陈彪
劉平%張寶和%連士傑%陳彪
류평%장보화%련사걸%진표
帕金森病%半胱氨酸%尿酸%认知障碍%老年人
帕金森病%半胱氨痠%尿痠%認知障礙%老年人
파금삼병%반광안산%뇨산%인지장애%노년인
Parkinson disease%Cysteine%Uric acid%Cognition disorders%Aged
目的探讨血清同型半胱氨酸（Hcy）和血尿酸（UA）的水平与帕金森病（PD）患者认知功能障碍的相关性。方法检测58例帕金森病患者和50例健康老人的血清同型半胱氨酸及血尿酸水平，采用简易精神状态检查（MMSE）量表对老年 PD 患者进行认知功能评分。结果老年帕金森病组的 Hcy 浓度[（25．89±3．01）μmol／L]显著高于健康老年组[（13．29±2．13）μmol／L]（P ＜0．01）；血尿酸水平显著低于健康老年组[（267．34±68．43）μmol／L 比（341．26±52．75）μmol／L，P ＜0．01]，并且 PD 伴认知障碍组的 Hcy 浓度显著高于 PD 无认知障碍组[（29．54±4．35）μmol／L 比（20．78±3．17）μmol／L ，P ＜0．05]，PD 伴认知障碍组的血尿酸水平显著低于 PD 无认知障碍组[（245．10±55．61）μmol／L 比（302．21±52．31）μmol／L ，P ＜0．05]。结论老年帕金森病患者会出现血清同型半胱氨酸水平升高及血尿酸水平的降低，其变化与程度认知功能障碍的发生有一定关联度。
目的探討血清同型半胱氨痠（Hcy）和血尿痠（UA）的水平與帕金森病（PD）患者認知功能障礙的相關性。方法檢測58例帕金森病患者和50例健康老人的血清同型半胱氨痠及血尿痠水平，採用簡易精神狀態檢查（MMSE）量錶對老年 PD 患者進行認知功能評分。結果老年帕金森病組的 Hcy 濃度[（25．89±3．01）μmol／L]顯著高于健康老年組[（13．29±2．13）μmol／L]（P ＜0．01）；血尿痠水平顯著低于健康老年組[（267．34±68．43）μmol／L 比（341．26±52．75）μmol／L，P ＜0．01]，併且 PD 伴認知障礙組的 Hcy 濃度顯著高于 PD 無認知障礙組[（29．54±4．35）μmol／L 比（20．78±3．17）μmol／L ，P ＜0．05]，PD 伴認知障礙組的血尿痠水平顯著低于 PD 無認知障礙組[（245．10±55．61）μmol／L 比（302．21±52．31）μmol／L ，P ＜0．05]。結論老年帕金森病患者會齣現血清同型半胱氨痠水平升高及血尿痠水平的降低，其變化與程度認知功能障礙的髮生有一定關聯度。
목적탐토혈청동형반광안산（Hcy）화혈뇨산（UA）적수평여파금삼병（PD）환자인지공능장애적상관성。방법검측58례파금삼병환자화50례건강노인적혈청동형반광안산급혈뇨산수평，채용간역정신상태검사（MMSE）량표대노년 PD 환자진행인지공능평분。결과노년파금삼병조적 Hcy 농도[（25．89±3．01）μmol／L]현저고우건강노년조[（13．29±2．13）μmol／L]（P ＜0．01）；혈뇨산수평현저저우건강노년조[（267．34±68．43）μmol／L 비（341．26±52．75）μmol／L，P ＜0．01]，병차 PD 반인지장애조적 Hcy 농도현저고우 PD 무인지장애조[（29．54±4．35）μmol／L 비（20．78±3．17）μmol／L ，P ＜0．05]，PD 반인지장애조적혈뇨산수평현저저우 PD 무인지장애조[（245．10±55．61）μmol／L 비（302．21±52．31）μmol／L ，P ＜0．05]。결론노년파금삼병환자회출현혈청동형반광안산수평승고급혈뇨산수평적강저，기변화여정도인지공능장애적발생유일정관련도。
Objective To study the relationship between the level of Homocysteine and Serum Uric Acid and cognitive dysfunction in elderly patients with Parkinson’s disease.Methods 50 healthy controls and 58 elderly PD patients,who were accepted in our hospital,were applied to test serum Hcy and UA level.Cognitive function were measured by Mini-mental State Examination(MMSE)scale in elderly PD.Results The serum Hcy level in elderly PD group were higher than that of healthy controls (P <0.01).The serum UA level in elderly PD group were lower than that of healthy controls (P <0.01).The serum Hcy level in elderly PD group with cognitive dysfunction were higher than that of elderly PD group without cognitive dysfunction(P <0.05 ).The serum UA level in elderly PD group with cognitive dysfunction were lower than that of elderly PD group without cognitive dysfunction(P <0.05) Conclusions Hyperhomocysteine and low serum Uric Acid level were existed in PD patients,which suggested that Hyperhomocysteine and low serum Uric Acid level were closely related to cognitive dysfunction in elderly patients with Parkinson’s disease.
