医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2015年
10期
1771-1773
,共3页
结肠癌%高迁移率族蛋白B1%肿瘤
結腸癌%高遷移率族蛋白B1%腫瘤
결장암%고천이솔족단백B1%종류
Colorectal Cancer%High-motility group box-1%Tumor
高迁移率族蛋白1（HMGB1）是近年来肿瘤研究的热点，HMGB1是非组蛋白染色体蛋白，在血管生成、抗原呈递、细胞自噬等方面参与肿瘤的发生、发展和转移。 HMGB1在结肠癌患者中高表达，血清HMGB1水平随疾病进展而明显增高，结肠癌伴肝转移患者的原发灶和转移灶均呈高表达，Dukes D期门静脉中HMGB1水平高于Dukes C期。 HMGB1在细胞内的表达部位与T淋巴细胞的浸润相关，后者可影响患者的5年生存率。因此，HMGB1可作为评估结肠癌病情发展及预后的指标。
高遷移率族蛋白1（HMGB1）是近年來腫瘤研究的熱點，HMGB1是非組蛋白染色體蛋白，在血管生成、抗原呈遞、細胞自噬等方麵參與腫瘤的髮生、髮展和轉移。 HMGB1在結腸癌患者中高錶達，血清HMGB1水平隨疾病進展而明顯增高，結腸癌伴肝轉移患者的原髮竈和轉移竈均呈高錶達，Dukes D期門靜脈中HMGB1水平高于Dukes C期。 HMGB1在細胞內的錶達部位與T淋巴細胞的浸潤相關，後者可影響患者的5年生存率。因此，HMGB1可作為評估結腸癌病情髮展及預後的指標。
고천이솔족단백1（HMGB1）시근년래종류연구적열점，HMGB1시비조단백염색체단백，재혈관생성、항원정체、세포자서등방면삼여종류적발생、발전화전이。 HMGB1재결장암환자중고표체，혈청HMGB1수평수질병진전이명현증고，결장암반간전이환자적원발조화전이조균정고표체，Dukes D기문정맥중HMGB1수평고우Dukes C기。 HMGB1재세포내적표체부위여T림파세포적침윤상관，후자가영향환자적5년생존솔。인차，HMGB1가작위평고결장암병정발전급예후적지표。
High-motility group box-1 ( HMGB1 ) is the focus of recent cancer research.HMGB1 is a non-histone chromosomal protein,which plays a critical role in cancer development,progression,and metasta-sis by enhancement of tumor angiogenesis,presenting antigen,and autophagy.Higher HMGB1 concentrations are found in the patients with colon cancer.Serum HMGB1 levels are significantly increased along the dis-ease progression.In patients of colon cancer with hepatocellular metastasis,HMGB1 is highly expressed in both the primary and metastasis foci,and the portal blood HMGB1 concentration is higher in Dukes D cases than in Dukes C cases.The expression position of HMGB1 is associated with lymphocyte infiltration ,which may affect the 5-year survival rate.Therefore,HMGB1 can be used as an index to assess the progression and prognosis of colorectal cancer.
