CAJ | 학술논문

心肌坏死后持续的炎症反应是导致急性心肌梗死（AMI）后心室重构（VR）的关键病理环节，其中Toll样受体（TLR）4介导的炎症信号途径在AMI后 VR中的关键作用越来越受到关注。目前，关于TLR4介导的自身炎症反应特点研究的比较多，关于TLR4介导的AMI后炎症反应的基础和临床研究仍在进行中。其介导的炎症信号途径在 AMI后的启动时间、高表达时间、维持时间及最佳药物干预时间等尚不明确，需要今后不断的深入研究将其一一阐释。
심기배사후지속적염증반응시도치급성심기경사（AMI）후심실중구（VR）적관건병리배절，기중Toll양수체（TLR）4개도적염증신호도경재AMI후 VR중적관건작용월래월수도관주。목전，관우TLR4개도적자신염증반응특점연구적비교다，관우TLR4개도적AMI후염증반응적기출화림상연구잉재진행중。기개도적염증신호도경재 AMI후적계동시간、고표체시간、유지시간급최가약물간예시간등상불명학，수요금후불단적심입연구장기일일천석。
Persistent inflammation is the key pathological circle on ventricular remodeling ( VR) after acute myocardial infarction(AMI),and more and more attention is paid to the role of Toll-like receptor 4 (TLR4) on VR after AMI.At present,it′s known that a lot about the inflammation reaction of TLR4, but the study on the inflammation reaction of TLR4 after AMI is still in progress.The start time, the peak time and the maintenance time of TLR4 on inflammatory reaction after AMI are still unclear , which need further research.