中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
CHINESE JOURNAL OF GENERAL PRACTITIONERS
2015年
6期
432-436
,共5页
朱立新%周美岑%崔向丽%冯林波%赵雪峰%何书励%李玉秀
硃立新%週美岑%崔嚮麗%馮林波%趙雪峰%何書勵%李玉秀
주립신%주미잠%최향려%풍림파%조설봉%하서려%리옥수
高尿酸血症%肥胖症%代谢疾病%横断面研究
高尿痠血癥%肥胖癥%代謝疾病%橫斷麵研究
고뇨산혈증%비반증%대사질병%횡단면연구
Hyperuricemia%Obesity%Metabolic diseases%Cross-sectional studies
目的 了解北京市昌平区南口镇农村人群高尿酸血症患病特点及其与血压、血糖和血脂等代谢异常的关系.方法 2014年7月1日至8月30日该地区18岁以上常住农村户籍居民体检者1 336例,比较不同年龄段者高尿酸血症的检出率.根据体检者年龄分为中青年组(20 ～ 59岁,686例)和老年组(60 ～ 96岁,650例),根据血尿酸水平从低到高分A、B、C、D4个组,每组334例,比较不同血尿酸水平者血压、血糖、血脂水平,分析高尿酸血症患者合并其他代谢异常的比例.结果 ①中青年组高尿酸血症检出率20.41％(140/686),显著性高于老年组的13.85％ (90/650) (x2=10.08,P=0.001),老年组收缩压、空腹血糖、TC、LDL-C水平显著高于中青年组[收缩压:(126.8±15.7)与(116.7±12.0)mmHg(1 mmHg=0.133 kPa),t=2.76,P=0.008;空腹血糖:(7.40±4.10)与(6.11±2.03) mmol/L,t=2.12,P=0.036;TC:(5.52±1.10)与(5.23±1.00) mmol/L,t=2.04,P=0.045;LDL-C:(3.5±0.7)与(2.4±0.9) mmol/L,t =2.21,P=0.029];②不同血尿酸水平的4组间比较:D组BMI、空腹血糖显著高于A、B、C组[A、B、C、D组的BMI:(24.19±3.37)、(25.49 ±3.42)、(25.61±3.49)和(26.44±3.88)kg/m2,t=2.78,P=0.008;空腹血糖:(6.34±1.34)、(6.09±1.51)、(6.40±1.98)和(8.19±1.52) mmol/L,t =2.80,P=0.007],C、D组的TG水平显著高于A、B两组[A、B、C、D组:(1.37 ±0.76)、(1.70±0.84)、(1.92 ±0.44)和(1.85±0.90)mmol/L,t =2.1,P=0.035];③高尿酸血症患者不合并其他代谢异常者仅占9.57％(22/230),合并1种代谢异常者占20.87％(48/230),合并2种以上代谢异常者占69.57％(160/230).结论 在农村人群尤其中青年人群中加强对高尿酸的筛查,及早发现与治疗,同时需加强对高尿酸血症及其伴随代谢异常的综合治疗和管理.
目的 瞭解北京市昌平區南口鎮農村人群高尿痠血癥患病特點及其與血壓、血糖和血脂等代謝異常的關繫.方法 2014年7月1日至8月30日該地區18歲以上常住農村戶籍居民體檢者1 336例,比較不同年齡段者高尿痠血癥的檢齣率.根據體檢者年齡分為中青年組(20 ～ 59歲,686例)和老年組(60 ～ 96歲,650例),根據血尿痠水平從低到高分A、B、C、D4箇組,每組334例,比較不同血尿痠水平者血壓、血糖、血脂水平,分析高尿痠血癥患者閤併其他代謝異常的比例.結果 ①中青年組高尿痠血癥檢齣率20.41％(140/686),顯著性高于老年組的13.85％ (90/650) (x2=10.08,P=0.001),老年組收縮壓、空腹血糖、TC、LDL-C水平顯著高于中青年組[收縮壓:(126.8±15.7)與(116.7±12.0)mmHg(1 mmHg=0.133 kPa),t=2.76,P=0.008;空腹血糖:(7.40±4.10)與(6.11±2.03) mmol/L,t=2.12,P=0.036;TC:(5.52±1.10)與(5.23±1.00) mmol/L,t=2.04,P=0.045;LDL-C:(3.5±0.7)與(2.4±0.9) mmol/L,t =2.21,P=0.029];②不同血尿痠水平的4組間比較:D組BMI、空腹血糖顯著高于A、B、C組[A、B、C、D組的BMI:(24.19±3.37)、(25.49 ±3.42)、(25.61±3.49)和(26.44±3.88)kg/m2,t=2.78,P=0.008;空腹血糖:(6.34±1.34)、(6.09±1.51)、(6.40±1.98)和(8.19±1.52) mmol/L,t =2.80,P=0.007],C、D組的TG水平顯著高于A、B兩組[A、B、C、D組:(1.37 ±0.76)、(1.70±0.84)、(1.92 ±0.44)和(1.85±0.90)mmol/L,t =2.1,P=0.035];③高尿痠血癥患者不閤併其他代謝異常者僅佔9.57％(22/230),閤併1種代謝異常者佔20.87％(48/230),閤併2種以上代謝異常者佔69.57％(160/230).結論 在農村人群尤其中青年人群中加彊對高尿痠的篩查,及早髮現與治療,同時需加彊對高尿痠血癥及其伴隨代謝異常的綜閤治療和管理.
목적 료해북경시창평구남구진농촌인군고뇨산혈증환병특점급기여혈압、혈당화혈지등대사이상적관계.방법 2014년7월1일지8월30일해지구18세이상상주농촌호적거민체검자1 336례,비교불동년령단자고뇨산혈증적검출솔.근거체검자년령분위중청년조(20 ～ 59세,686례)화노년조(60 ～ 96세,650례),근거혈뇨산수평종저도고분A、B、C、D4개조,매조334례,비교불동혈뇨산수평자혈압、혈당、혈지수평,분석고뇨산혈증환자합병기타대사이상적비례.결과 ①중청년조고뇨산혈증검출솔20.41％(140/686),현저성고우노년조적13.85％ (90/650) (x2=10.08,P=0.001),노년조수축압、공복혈당、TC、LDL-C수평현저고우중청년조[수축압:(126.8±15.7)여(116.7±12.0)mmHg(1 mmHg=0.133 kPa),t=2.76,P=0.008;공복혈당:(7.40±4.10)여(6.11±2.03) mmol/L,t=2.12,P=0.036;TC:(5.52±1.10)여(5.23±1.00) mmol/L,t=2.04,P=0.045;LDL-C:(3.5±0.7)여(2.4±0.9) mmol/L,t =2.21,P=0.029];②불동혈뇨산수평적4조간비교:D조BMI、공복혈당현저고우A、B、C조[A、B、C、D조적BMI:(24.19±3.37)、(25.49 ±3.42)、(25.61±3.49)화(26.44±3.88)kg/m2,t=2.78,P=0.008;공복혈당:(6.34±1.34)、(6.09±1.51)、(6.40±1.98)화(8.19±1.52) mmol/L,t =2.80,P=0.007],C、D조적TG수평현저고우A、B량조[A、B、C、D조:(1.37 ±0.76)、(1.70±0.84)、(1.92 ±0.44)화(1.85±0.90)mmol/L,t =2.1,P=0.035];③고뇨산혈증환자불합병기타대사이상자부점9.57％(22/230),합병1충대사이상자점20.87％(48/230),합병2충이상대사이상자점69.57％(160/230).결론 재농촌인군우기중청년인군중가강대고뇨산적사사,급조발현여치료,동시수가강대고뇨산혈증급기반수대사이상적종합치료화관리.
Objective To investigate the prevalence of hyperuricemia in health check-up population of Beijing suburb.Methods Total 1 336 rural residents in Nankou Township of Beijing received health check-up from July to Aug 2014,including 686 subjects aged 20-59 years (young/middle-aged group) and 650 subjects aged 60-96 years (elderly group).The blood pressure and body mass index (BMI) were measured;serum uric acid (SUA),fasting blood glucose (FBG) and blood lipids (TG,TC,HDL-C,LDL-C) were determined.The SUA levels ＞ 420 μmol/L for male and ＞ 360 μmol/L for female were defined as hyperuricemia.Results The four quartiles of SUA levels were 27.00-254.59 μmol/L (Q1),254.60-302.35 μmol/L (Q2),302.36-359.78 μmol/L(Q3) and 359.79-702.0 μmol/L (Q4).The prevalence of hyperuricemia was significantly higher in young/middle-aged group than that in elderly group [20.41％ (140/686) vs.13.85％ (90/650),x2 =10.08,P =0.001 5],the systolic blood pressure [SBP,(126.8±15.7) vs.(116.7±12.0)mmHg(1 mmHg=0.133 kPa),t=2.76,P=0.008],FBG [(7.40±4.10) vs.(6.11 ±2.03)mmol/L,t=2.12,P=0.036],TC [(5.52±1.10) vs.(5.23±1.00)mmol/L,t =2.04,P =0.045],LDL-C [(3.5 ±0.7) vs.(2.4 ±0.9)mmol/L,t =2.21,P =0.029]in young/middle-aged group were significantly higher than those in elderly group.BMI,FBG were significantly higher in Q4 than those in other quartiles [BMI:(26.44 ± 3.88) vs.(24.19 ± 3.37),(25.49±3.42) and (25.61 ±3.49)kg/m2,t =2.78,P=0.008;FBG:(8.19 ±1.52) vs.(6.34±1.34),(6.09 ± 1.51) and (6.40 ± 1.98) mmol/L,t =2.80,P =0.007].The triglyceride (TG) levels in group Q3 and Q4 [(1.85 ± 0.90) and (1.92 ± 0.44) mmol/L] were higher than those in Q1 and Q2 [(1.37 ±0.76) and (1.70 ±0.84) mmol/L,t =2.1,P =0.035].Only 9.57％ subjects (22/230)with hyperuricemia was not combined with metabolic disorder;subjects combined with one and two metabolic disorders accounted for 20.87％ (48/230) and 69.57％ (160/230),respectively.Conclusion Screening for hyperuricemia is important for comprehensiye treatment and management of hyperuricemia in rural residents,especially in the young and middle-aged population.
