中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
6期
1030-1031,1032
,共3页
杨海霞%刘延新%李凤超%邢玉仁
楊海霞%劉延新%李鳳超%邢玉仁
양해하%류연신%리봉초%형옥인
电感耦合等离子体原子发射光谱法%阿戈美拉汀%镍
電感耦閤等離子體原子髮射光譜法%阿戈美拉汀%鎳
전감우합등리자체원자발사광보법%아과미랍정%얼
Inductive coupled plasma atomic emission spectrometry%Agomelatine%Nicke
目的：：建立阿戈美拉汀中微量镍的测定方法。方法：采用电感耦合等离子体原子发射光谱法,在221.648 nm处测定,用阿戈美拉汀炽灼后的残渣制备供试品溶液,采用标准曲线法测定镍的含量。结果：镍在0.025~1.000μg·ml-1浓度范围内线性关系良好(r=0.9998),精密度RSD为0.63%,检出限为0.0008μg·ml-1,定量限为0.003μg·ml-1,平均回收率为99.4%(RSD为2.20%,n=9)。结论：该法简便、灵敏、准确性好,可用于阿戈美拉汀中微量镍的测定。
目的：：建立阿戈美拉汀中微量鎳的測定方法。方法：採用電感耦閤等離子體原子髮射光譜法,在221.648 nm處測定,用阿戈美拉汀熾灼後的殘渣製備供試品溶液,採用標準麯線法測定鎳的含量。結果：鎳在0.025~1.000μg·ml-1濃度範圍內線性關繫良好(r=0.9998),精密度RSD為0.63%,檢齣限為0.0008μg·ml-1,定量限為0.003μg·ml-1,平均迴收率為99.4%(RSD為2.20%,n=9)。結論：該法簡便、靈敏、準確性好,可用于阿戈美拉汀中微量鎳的測定。
목적：：건립아과미랍정중미량얼적측정방법。방법：채용전감우합등리자체원자발사광보법,재221.648 nm처측정,용아과미랍정치작후적잔사제비공시품용액,채용표준곡선법측정얼적함량。결과：얼재0.025~1.000μg·ml-1농도범위내선성관계량호(r=0.9998),정밀도RSD위0.63%,검출한위0.0008μg·ml-1,정량한위0.003μg·ml-1,평균회수솔위99.4%(RSD위2.20%,n=9)。결론：해법간편、령민、준학성호,가용우아과미랍정중미량얼적측정。
Objective:To establish a method for the determination of trace nickel in agomelatine. Methods:An inductive coupled plasma atomic emission spectrometry method was applied in the determination at 221. 648 nm. The sample solution was prepared by the ignited residue of agomelatine. The content of nickel was determined using the standard curve. Results:The linear range was 0. 025-1. 000 μg·ml-1(r=0. 999 8). The RSD of precision was 0. 63%. The detection limit was 0. 000 8μg·ml-1. The quantitative limit was 0. 003μg·ml-1 . The average recovery was 99. 4% with RSD of 2. 20%. The RSD of repeatability was 1. 33%. Conclusion:The method is simple, sensitive and accurate in the determination of trace nickel in agomelatine.
