中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
6期
922-925
,共4页
张淑香%许贵军%周金霄%杨书彬%丛慧芳
張淑香%許貴軍%週金霄%楊書彬%叢慧芳
장숙향%허귀군%주금소%양서빈%총혜방
痛愈舒胶囊%痛经%药效学
痛愈舒膠囊%痛經%藥效學
통유서효낭%통경%약효학
Tongyushu capsule%Dysmenorrhea%Pharmacodynamics
目的：：观察痛愈舒胶囊对痛经的治疗作用。方法：采用大鼠静脉注射缩宫素的方法，观察痛愈舒胶囊对大鼠在体子宫平滑肌的影响；采用小鼠腹腔注射缩宫素的方法，观察痛愈舒胶囊对痛经模型小鼠的影响；采用醋酸扭体法，观察痛愈舒胶囊的止痛作用；采用二甲苯致小鼠耳肿胀的方法，观察痛愈舒胶囊的抗炎作用；采用冰水浴及皮下注射肾上腺素的方法，观察痛愈舒胶囊对大鼠急性血瘀模型的影响。结果：与模型组比较，痛愈舒胶囊各给药组大鼠在体子宫平滑肌收缩幅度明显降低(P<0.05)，小鼠15 min 内缩宫素及醋酸分别致扭体反应发生次数均明显减少(P<0.05)，小鼠耳肿胀程度明显减小(P<0.05)，全血黏度、血浆黏度、红细胞压积、红细胞沉降率及红细胞电泳时间均明显降低(P<0.05)。结论：痛愈舒胶囊具有明显抑制大鼠在体子宫平滑肌过度收缩、缓解痛经、抗炎、止痛及改善血液流变学作用，对痛经具有很好的治疗作用。
目的：：觀察痛愈舒膠囊對痛經的治療作用。方法：採用大鼠靜脈註射縮宮素的方法，觀察痛愈舒膠囊對大鼠在體子宮平滑肌的影響；採用小鼠腹腔註射縮宮素的方法，觀察痛愈舒膠囊對痛經模型小鼠的影響；採用醋痠扭體法，觀察痛愈舒膠囊的止痛作用；採用二甲苯緻小鼠耳腫脹的方法，觀察痛愈舒膠囊的抗炎作用；採用冰水浴及皮下註射腎上腺素的方法，觀察痛愈舒膠囊對大鼠急性血瘀模型的影響。結果：與模型組比較，痛愈舒膠囊各給藥組大鼠在體子宮平滑肌收縮幅度明顯降低(P<0.05)，小鼠15 min 內縮宮素及醋痠分彆緻扭體反應髮生次數均明顯減少(P<0.05)，小鼠耳腫脹程度明顯減小(P<0.05)，全血黏度、血漿黏度、紅細胞壓積、紅細胞沉降率及紅細胞電泳時間均明顯降低(P<0.05)。結論：痛愈舒膠囊具有明顯抑製大鼠在體子宮平滑肌過度收縮、緩解痛經、抗炎、止痛及改善血液流變學作用，對痛經具有很好的治療作用。
목적：：관찰통유서효낭대통경적치료작용。방법：채용대서정맥주사축궁소적방법，관찰통유서효낭대대서재체자궁평활기적영향；채용소서복강주사축궁소적방법，관찰통유서효낭대통경모형소서적영향；채용작산뉴체법，관찰통유서효낭적지통작용；채용이갑분치소서이종창적방법，관찰통유서효낭적항염작용；채용빙수욕급피하주사신상선소적방법，관찰통유서효낭대대서급성혈어모형적영향。결과：여모형조비교，통유서효낭각급약조대서재체자궁평활기수축폭도명현강저(P<0.05)，소서15 min 내축궁소급작산분별치뉴체반응발생차수균명현감소(P<0.05)，소서이종창정도명현감소(P<0.05)，전혈점도、혈장점도、홍세포압적、홍세포침강솔급홍세포전영시간균명현강저(P<0.05)。결론：통유서효낭구유명현억제대서재체자궁평활기과도수축、완해통경、항염、지통급개선혈액류변학작용，대통경구유흔호적치료작용。
Objective:To observe the therapeutic effects of Tongyushu capsules on dysmenorrhea. Methods:With the intravenous injection of oxytocin in rats, the influence of Tongyushu capsules on rat uterine smooth muscle was observed in vivo. With the intraper-itoneal injection of oxytocin to replicate the mouse model of dysmenorrhea, the effect of Tongyushu capsules on dysmenorrhea was ob-served. Using acetic acid writhing method, the effect of relieving pain Tongyushu capsules in mice was observed. By the method of ear swelling induced by xylene in mice, the anti-inflammatory effect of Tongyushu capsules was observed. By the method of ice water bath and subcutaneous injection of adrenaline, the influence of Tongyushu capsules on the acute blood stasis model in rats was observed. Results:Compared with those of the model group, the contraction of uterine smooth muscle of the groups treated with Tongyushu cap-sules at various dosage was decreased obviously (P<0. 05), the number of body torsion reaction induced by oxytocin and acetic acid in mice was obviously decreased in 15 min (P<0. 05), the degree of ear swelling in mice treated with Tongyushu capsules was signifi-cantly reduced (P<0. 05), and the whole blood viscosity, plasma viscosity, hematokrit, erythrocyte sedimentation rate and erythro-cyte electrophoresis time were significantly decreased (P<0. 05). Conclusion:Tongyushu capsules have obvious effects of the inhibi-tion of excessive contraction of uterine smooth muscle, dysmenorrhea alleviation, anti-inflammation and relieving pain, which show good therapeutic effect on dysmenorrhea.
