江西中医药大学学报
江西中醫藥大學學報
강서중의약대학학보
Journal of Jiangxi University of Traditional Chinese Medicine
2015年
3期
79-81
,共3页
山豆根%水煎液%急性毒性
山豆根%水煎液%急性毒性
산두근%수전액%급성독성
Radix et Rhizome Sophorae Tonkinensis%Water Extract%Acute Toxicity
目的：实验研究山豆根水煎液对小鼠的急性毒性，为山豆根的临床安全与合理用药提供实验依据。方法：采用灌胃给药的方式，按照经典急性毒性实验方法测定山豆根水煎液的小鼠口服半数致死量（ LD50）值，观察小鼠中毒症状，记录小鼠的累计死亡数和体重变化。结果：小鼠口服山豆根水煎液的LD50及95％可信限为47．918（45．192～50．665） g· kg－1，主要毒性症状为闭眼、怠动、腹式呼吸等。结论：小鼠一次性口服大剂量山豆根水煎液可造成急性中毒，中毒表现主要为肝脏的损伤。
目的：實驗研究山豆根水煎液對小鼠的急性毒性，為山豆根的臨床安全與閤理用藥提供實驗依據。方法：採用灌胃給藥的方式，按照經典急性毒性實驗方法測定山豆根水煎液的小鼠口服半數緻死量（ LD50）值，觀察小鼠中毒癥狀，記錄小鼠的纍計死亡數和體重變化。結果：小鼠口服山豆根水煎液的LD50及95％可信限為47．918（45．192～50．665） g· kg－1，主要毒性癥狀為閉眼、怠動、腹式呼吸等。結論：小鼠一次性口服大劑量山豆根水煎液可造成急性中毒，中毒錶現主要為肝髒的損傷。
목적：실험연구산두근수전액대소서적급성독성，위산두근적림상안전여합리용약제공실험의거。방법：채용관위급약적방식，안조경전급성독성실험방법측정산두근수전액적소서구복반수치사량（ LD50）치，관찰소서중독증상，기록소서적루계사망수화체중변화。결과：소서구복산두근수전액적LD50급95％가신한위47．918（45．192～50．665） g· kg－1，주요독성증상위폐안、태동、복식호흡등。결론：소서일차성구복대제량산두근수전액가조성급성중독，중독표현주요위간장적손상。
Objective:To study the acute toxicity of water extract of Radix et Rhizoma Sophorae Tonkinensis ( RRST) in mice to provide experimental data for safe use in clinal.Methods:With the method of lavage for medicine, the LD50 of water extract of RRST were test-ed by the classical methods of acute toxicity.Observed the symptoms of the acute toxic including the number of death animals and the weight-changes of live mice.Results:The LD50 (95%cconfidence interval) of water extract of RRST was 47.918(45.192~50.665) g· kg-1 in mice.The main acute tixical symptoms were eyes closed, lazied, shortness of breath and so on.Conclusion:Mice taking high-dose water decoction of RRST one-time can cause acute toxicity and poisoning mainly for liver damage.
