CAJ | 학술논문

氧化应激是机体内一种有害的氧化还原失衡状态，是导致疾病的重要因素之一。围产期奶牛由于营养物质摄入不足、能量代谢加快、内分泌激素急剧变化等原因导致能量需求和耗氧量需求增大，活性氧生成增多，进而导致氧化应激的发生及免疫功能下降，疾病易感性的增加。围产期易发的疾病如乳房炎、酮病等都与氧化应激有一定的关联。氧化应激导致疾病易发的原因一方面是通过对生物大分子的直接作用，增加了炎症反应时的组织损伤，另一方面是通过对免疫系统的作用，造成机体免疫机能下降。
양화응격시궤체내일충유해적양화환원실형상태，시도치질병적중요인소지일。위산기내우유우영양물질섭입불족、능량대사가쾌、내분비격소급극변화등원인도치능량수구화모양량수구증대，활성양생성증다，진이도치양화응격적발생급면역공능하강，질병역감성적증가。위산기역발적질병여유방염、동병등도여양화응격유일정적관련。양화응격도치질병역발적원인일방면시통과대생물대분자적직접작용，증가료염증반응시적조직손상，령일방면시통과대면역계통적작용，조성궤체면역궤능하강。
Oxidative stress is a redox imbalance state which is harmful to the body, and it is also one of the important factors that lead to diseases. Insufficient nutrient intake, higher energy metabolism rate and dramatic changes of hormone tend to cause the increasement of energy demand and oxygen consumption and increase production of reactive oxygen species,leading to the incidence of oxidative stress, as well as the decline of immune function and the increasing of disease susceptibility. Perinatal cow diseases such as mastitis and ketosis have some relevance to oxidative stress. Oxidative stress causes the disease through two pathway: one is through direct effects on biological macro molecules, increasing tissue damage during inflammation, and the other is through the role of the immune system, resulting in decreased immune function.