中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2015年
6期
423-426
,共4页
糖尿病,2型%冠状动脉狭窄%血糖变异性
糖尿病,2型%冠狀動脈狹窄%血糖變異性
당뇨병,2형%관상동맥협착%혈당변이성
Diabetes mellitus,type 2%Coronary stenosis%Glucose variability
目的 探讨2型糖尿病合并冠心病患者血糖变异性与冠状动脉狭窄程度的相关性.方法 选择行冠状动脉造影术的2型糖尿病患者80例为研究对象,据冠状动脉造影结果,48例2型糖尿病合并冠心病患者为冠心病组,32例2型糖尿病不合并冠心病患者作为对照组.入院后均行72 h动态血糖监测,计算平均血糖(MBG)、血糖水平标准差(SDBG)、日内平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)、最大血糖波动幅度(LAGE)、平均餐后血糖漂移幅度(MPPGE),并分析冠状动脉狭窄程度(以Gensini评分表示)的危险因素.结果 冠心病组LAGE、SDBG、MAGE、MPPGE、MODD显著高于对照组[(11.4±3.6) mmol/L比(8.2±1.9) mmol/L、(3.4±1.4)mmol/L比(1.9±0.6) mmol/L、(7.1 ±2.7) mmol/L比(4.8±1.4) mmol/L、(6.6±1.8) mmol/L比(4.6±1.5) mmol/L、(3.3±1.2) mmol/L比(2.5±0.9) mmol/L],差异有统计学意义(P＜0.05),两组MBG比较差异无统计学意义[(10.2±2.8) mmol/L比(9.3±2.2) mmol/L](P＞ 0.05).Pearson相关分析显示,MPPGE、MODD、LAGE与Gensini评分呈正相关(r=0.509,0.357和0.338;P＜ 0.05);LVEF与Gensini评分呈负相关(r=-0.372,P＜0.05).结论 2型糖尿病合并冠心病患者血糖变异性明显增大,MPPGE、MODD和LAGE与冠状动脉狭窄程度呈正相关.
目的 探討2型糖尿病閤併冠心病患者血糖變異性與冠狀動脈狹窄程度的相關性.方法 選擇行冠狀動脈造影術的2型糖尿病患者80例為研究對象,據冠狀動脈造影結果,48例2型糖尿病閤併冠心病患者為冠心病組,32例2型糖尿病不閤併冠心病患者作為對照組.入院後均行72 h動態血糖鑑測,計算平均血糖(MBG)、血糖水平標準差(SDBG)、日內平均血糖波動幅度(MAGE)、日間血糖平均絕對差(MODD)、最大血糖波動幅度(LAGE)、平均餐後血糖漂移幅度(MPPGE),併分析冠狀動脈狹窄程度(以Gensini評分錶示)的危險因素.結果 冠心病組LAGE、SDBG、MAGE、MPPGE、MODD顯著高于對照組[(11.4±3.6) mmol/L比(8.2±1.9) mmol/L、(3.4±1.4)mmol/L比(1.9±0.6) mmol/L、(7.1 ±2.7) mmol/L比(4.8±1.4) mmol/L、(6.6±1.8) mmol/L比(4.6±1.5) mmol/L、(3.3±1.2) mmol/L比(2.5±0.9) mmol/L],差異有統計學意義(P＜0.05),兩組MBG比較差異無統計學意義[(10.2±2.8) mmol/L比(9.3±2.2) mmol/L](P＞ 0.05).Pearson相關分析顯示,MPPGE、MODD、LAGE與Gensini評分呈正相關(r=0.509,0.357和0.338;P＜ 0.05);LVEF與Gensini評分呈負相關(r=-0.372,P＜0.05).結論 2型糖尿病閤併冠心病患者血糖變異性明顯增大,MPPGE、MODD和LAGE與冠狀動脈狹窄程度呈正相關.
목적 탐토2형당뇨병합병관심병환자혈당변이성여관상동맥협착정도적상관성.방법 선택행관상동맥조영술적2형당뇨병환자80례위연구대상,거관상동맥조영결과,48례2형당뇨병합병관심병환자위관심병조,32례2형당뇨병불합병관심병환자작위대조조.입원후균행72 h동태혈당감측,계산평균혈당(MBG)、혈당수평표준차(SDBG)、일내평균혈당파동폭도(MAGE)、일간혈당평균절대차(MODD)、최대혈당파동폭도(LAGE)、평균찬후혈당표이폭도(MPPGE),병분석관상동맥협착정도(이Gensini평분표시)적위험인소.결과 관심병조LAGE、SDBG、MAGE、MPPGE、MODD현저고우대조조[(11.4±3.6) mmol/L비(8.2±1.9) mmol/L、(3.4±1.4)mmol/L비(1.9±0.6) mmol/L、(7.1 ±2.7) mmol/L비(4.8±1.4) mmol/L、(6.6±1.8) mmol/L비(4.6±1.5) mmol/L、(3.3±1.2) mmol/L비(2.5±0.9) mmol/L],차이유통계학의의(P＜0.05),량조MBG비교차이무통계학의의[(10.2±2.8) mmol/L비(9.3±2.2) mmol/L](P＞ 0.05).Pearson상관분석현시,MPPGE、MODD、LAGE여Gensini평분정정상관(r=0.509,0.357화0.338;P＜ 0.05);LVEF여Gensini평분정부상관(r=-0.372,P＜0.05).결론 2형당뇨병합병관심병환자혈당변이성명현증대,MPPGE、MODD화LAGE여관상동맥협착정도정정상관.
Objective To investigate the correlation between glucose variability and coronary stenosis in type 2 diabetes mellitus (T2DM) combined with coronary heart disease (CHD) patients.Methods Eighty patients with T2DM who had undergone coronary angiography were selected.According to the result of coronary angiography,the patients were divided into 2 groups:48 T2DM combined with CHD patients as CHD group,and 32 T2DM combined without CHD patients as control group.All patients underwent continuous glucose monitoring (CGM) for 72 h,and the mean blood glucose (MBG),standard deviation of blood glucose (SDBG),daily mean amplitude of glycemic excursion (MAGE),absolute means of daily differences (MODD),largest amplitude of blood glucose excursion (LAGE) and mean postprandial glucose excursion (MPPGE) were computed.The risk factor of coronary stenosis (using Gensini score) was analyzed.Results The LAGE,SDBG,MAGE,MPPGE,MODD in CHD group were significantly higher than those in control group:(11.4 ± 3.6) mmol/L vs.(8.2 ± 1.9) mmol/L,(3.4 ± 1.4) mmol/L vs.(1.9 ± 0.6) mmol/L,(7.1 ± 2.7) mmol/L vs.(4.8 ± 1.4) mmol/L,(6.6 ± 1.8) mmol/L vs.(4.6 ± 1.5) mmol/L,(3.3 ± 1.2) mmol/L vs.(2.5 ± 0.9) mmol/L,and there were statistical differences (P ＜ 0.05).There was no statistical difference in MBG between CHD group and control group:(10.2 ± 2.8) mmol/L vs.(9.3 ± 2.2) mmol/L,P ＞ 0.05.The Pearson correlation analysis result showed that the MPPGE,MODD and LAGE had positive correlation with Gensini score (r =0.509,0.357 and 0.338;P ＜ 0.05);and the LVEF had negative correlation with Gensini score (r =-0.372,P ＜ 0.05).Conclusions Glucose variability in patients with T2DM combined with CHD is markedly enhanced.MPPGE,MODD and IAGE are positively correlated with the severity of coronary stenosis.
