黑龙江医药
黑龍江醫藥
흑룡강의약
HEILONGJIANG MEDICAL JOURNAL
2015年
3期
485-487,488
,共4页
黄亚丽%杨丽萍%廖建军%韦湘%黄继贤%谢治军%黄刚
黃亞麗%楊麗萍%廖建軍%韋湘%黃繼賢%謝治軍%黃剛
황아려%양려평%료건군%위상%황계현%사치군%황강
难治性多发性骨髓瘤%T淋巴细胞亚群%自然杀伤细胞%疗效
難治性多髮性骨髓瘤%T淋巴細胞亞群%自然殺傷細胞%療效
난치성다발성골수류%T림파세포아군%자연살상세포%료효
Replased/Refractory MultiPle myeloma%T cell subgroups%Natural killer cell
目的:研究多发性骨髓瘤患者外周血T淋巴细胞亚群与自然杀伤(NK)细胞的表达水平,探讨其细胞免疫功能与临床疗效的关系,并为判断、预测容易转归为难治患者提供具有参考价值的指标。方法:采用流式细胞术检测64例初治骨髓瘤患者化疗前及化疗中和全疗程结束后外周血T淋巴细胞亚群与NK细胞的表达水平。按化疗结果分完全缓解组、部分缓解组和难治组,与健康对照组比较。结果:①完全缓解组Th细胞、Ts细胞和NK细胞与对照组的差别无统计学意义。②部分缓解组Th细胞下降与对照组的差别有统计学意义。③难治组Th细胞、Ts细胞和NK细胞均呈明显下降,与对照组相比差别明显。④在最终死亡的三个患者,NK细胞百分比均在3%以下。结论:治疗后Th细胞、Ts细胞和NK细胞如果下降不明显,则提示该患者预后相对乐观,如果上述指标均明显下降,则提示预后不良。对于NK细胞严重降低的患者,提示预后极差。
目的:研究多髮性骨髓瘤患者外週血T淋巴細胞亞群與自然殺傷(NK)細胞的錶達水平,探討其細胞免疫功能與臨床療效的關繫,併為判斷、預測容易轉歸為難治患者提供具有參攷價值的指標。方法:採用流式細胞術檢測64例初治骨髓瘤患者化療前及化療中和全療程結束後外週血T淋巴細胞亞群與NK細胞的錶達水平。按化療結果分完全緩解組、部分緩解組和難治組,與健康對照組比較。結果:①完全緩解組Th細胞、Ts細胞和NK細胞與對照組的差彆無統計學意義。②部分緩解組Th細胞下降與對照組的差彆有統計學意義。③難治組Th細胞、Ts細胞和NK細胞均呈明顯下降,與對照組相比差彆明顯。④在最終死亡的三箇患者,NK細胞百分比均在3%以下。結論:治療後Th細胞、Ts細胞和NK細胞如果下降不明顯,則提示該患者預後相對樂觀,如果上述指標均明顯下降,則提示預後不良。對于NK細胞嚴重降低的患者,提示預後極差。
목적:연구다발성골수류환자외주혈T림파세포아군여자연살상(NK)세포적표체수평,탐토기세포면역공능여림상료효적관계,병위판단、예측용역전귀위난치환자제공구유삼고개치적지표。방법:채용류식세포술검측64례초치골수류환자화료전급화료중화전료정결속후외주혈T림파세포아군여NK세포적표체수평。안화료결과분완전완해조、부분완해조화난치조,여건강대조조비교。결과:①완전완해조Th세포、Ts세포화NK세포여대조조적차별무통계학의의。②부분완해조Th세포하강여대조조적차별유통계학의의。③난치조Th세포、Ts세포화NK세포균정명현하강,여대조조상비차별명현。④재최종사망적삼개환자,NK세포백분비균재3%이하。결론:치료후Th세포、Ts세포화NK세포여과하강불명현,칙제시해환자예후상대악관,여과상술지표균명현하강,칙제시예후불량。대우NK세포엄중강저적환자,제시예후겁차。
Objective:To investigate the T cell subgroups and Natural Killer(NK)cell’s expression level of peripheral blood in Multiple myeloma patients to discuss the relationship of their cellular immune function and clinical curative effect. Methods:Flow cytometry was applied to detect T cell subgroups and NK cell’s expression level of peripheral blood in 64 MM patients with chemo-therapy and 58 normal controls. Results:①The ratio of T lymphocyte subgroup helper T cell,and suppressor T cell and NK cell in CR were close to the normal controls’.②The ratio of Th in the 35PR patients was significant differences compared to normal controls’.③The ratio of Th,Ts and NK in 23 refractory cases were statistically significant low than the controls’.④In the 3 died patients the ratio of NK was lower 3%. Conclusions: If the ratio of T lymphocyte subgroup Th cel,and Ts cell and NK cell had no significant differenc-es, the prognosis would be optimistic. In contrast, the patints would have unfavourable prognosis. Especially, if the ratio of NK cell had significant differences, death would be the undesired result.