国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
11期
1582-1584,1588
,共4页
临床研究%抑郁症%脑梗死%血清细胞因子
臨床研究%抑鬱癥%腦梗死%血清細胞因子
림상연구%억욱증%뇌경사%혈청세포인자
Clinical study%Depression%Cerebral infarction%Serum cell factors
目的 探析血清细胞因子、IL-1 β、IL-6、TNF-α水平与脑梗死后抑郁症的相关性研究.方法 入选我院2013年5月至2014年4月脑梗死后抑郁症患者80例为研究组,同期入选脑梗死后无抑郁症患者80例为对照组,进行ELISA法检测血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1(IL-1)水平,同时服用百忧解抗抑郁药物,连续服用1个月,观察两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平;观察不同程度抑郁者的血清细胞因子水平;比较脑梗死后抑郁症治疗前后血清细胞因子水平.结果 研究组的TNF-α为(32.2±7.5)ng/L、IL-6为(12.9±3.8) ng/L、IL-1 β为(40.9-4.6) ng/L,对照组TNF-α为(19.7±4.1) ng/L、IL-6为(5.2±2.1)ng/L、IL-1β为(16.6±3.1) ng/L,两组比较差异有统计学意义(P＜0.05);血清细胞因子水平随着脑梗死后抑郁症程度加重而逐渐升高,重度抑郁症患者的TNF-α为(6.5±3.2) ng/L、IL-6为(6.7±1.7) ng/L、IL-1 β为(24.3±2.7)ng/L,轻度抑郁症患者的TNF-α为(39.2±7.4)ng/L、IL-6为(19.8±6.4)ng/L、IL-1β为(42.4±5.6)ng/L,中度抑郁症患者的TNF-α为(29.7±5.1) ng/L、IL-6为(9.2±3.1)ng/L、IL-1 β为(31.6±3.1)ng/L,重度抑郁症患者血清细胞因子水平与轻、重度抑郁症患者比较差异有统计学意义(P＜0.05);中度抑郁症患者的血清细胞因子水平显著高于轻度抑郁症患者,差异有统计学意义(P＜0.05);脑梗死后抑郁症治疗后的血清细胞因子水平[TNF-α(23.4±3.9) ng/L)、IL-6(7.4±2.7) ng/L、IL-1 β(22.4±3.4) ng/L)]显著低于治疗前[(TNF-α(32.2±7.5) ng/L)、IL-6(12.9±3.8) ng/L、IL-1[β (40.9±4.6) ng/L)],差异有统计学意义(P＜0.05).结论 血清细胞因子水平与脑梗死后抑郁症密切相关,可直接反映脑梗死后抑郁症的病情进展.
目的 探析血清細胞因子、IL-1 β、IL-6、TNF-α水平與腦梗死後抑鬱癥的相關性研究.方法 入選我院2013年5月至2014年4月腦梗死後抑鬱癥患者80例為研究組,同期入選腦梗死後無抑鬱癥患者80例為對照組,進行ELISA法檢測血清腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)、白細胞介素-1(IL-1)水平,同時服用百憂解抗抑鬱藥物,連續服用1箇月,觀察兩組血清腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)、白細胞介素-1β(IL-1β)水平;觀察不同程度抑鬱者的血清細胞因子水平;比較腦梗死後抑鬱癥治療前後血清細胞因子水平.結果 研究組的TNF-α為(32.2±7.5)ng/L、IL-6為(12.9±3.8) ng/L、IL-1 β為(40.9-4.6) ng/L,對照組TNF-α為(19.7±4.1) ng/L、IL-6為(5.2±2.1)ng/L、IL-1β為(16.6±3.1) ng/L,兩組比較差異有統計學意義(P＜0.05);血清細胞因子水平隨著腦梗死後抑鬱癥程度加重而逐漸升高,重度抑鬱癥患者的TNF-α為(6.5±3.2) ng/L、IL-6為(6.7±1.7) ng/L、IL-1 β為(24.3±2.7)ng/L,輕度抑鬱癥患者的TNF-α為(39.2±7.4)ng/L、IL-6為(19.8±6.4)ng/L、IL-1β為(42.4±5.6)ng/L,中度抑鬱癥患者的TNF-α為(29.7±5.1) ng/L、IL-6為(9.2±3.1)ng/L、IL-1 β為(31.6±3.1)ng/L,重度抑鬱癥患者血清細胞因子水平與輕、重度抑鬱癥患者比較差異有統計學意義(P＜0.05);中度抑鬱癥患者的血清細胞因子水平顯著高于輕度抑鬱癥患者,差異有統計學意義(P＜0.05);腦梗死後抑鬱癥治療後的血清細胞因子水平[TNF-α(23.4±3.9) ng/L)、IL-6(7.4±2.7) ng/L、IL-1 β(22.4±3.4) ng/L)]顯著低于治療前[(TNF-α(32.2±7.5) ng/L)、IL-6(12.9±3.8) ng/L、IL-1[β (40.9±4.6) ng/L)],差異有統計學意義(P＜0.05).結論 血清細胞因子水平與腦梗死後抑鬱癥密切相關,可直接反映腦梗死後抑鬱癥的病情進展.
목적 탐석혈청세포인자、IL-1 β、IL-6、TNF-α수평여뇌경사후억욱증적상관성연구.방법 입선아원2013년5월지2014년4월뇌경사후억욱증환자80례위연구조,동기입선뇌경사후무억욱증환자80례위대조조,진행ELISA법검측혈청종류배사인자-α(TNF-α)、백세포개소-6(IL-6)、백세포개소-1(IL-1)수평,동시복용백우해항억욱약물,련속복용1개월,관찰량조혈청종류배사인자-α(TNF-α)、백세포개소-6(IL-6)、백세포개소-1β(IL-1β)수평;관찰불동정도억욱자적혈청세포인자수평;비교뇌경사후억욱증치료전후혈청세포인자수평.결과 연구조적TNF-α위(32.2±7.5)ng/L、IL-6위(12.9±3.8) ng/L、IL-1 β위(40.9-4.6) ng/L,대조조TNF-α위(19.7±4.1) ng/L、IL-6위(5.2±2.1)ng/L、IL-1β위(16.6±3.1) ng/L,량조비교차이유통계학의의(P＜0.05);혈청세포인자수평수착뇌경사후억욱증정도가중이축점승고,중도억욱증환자적TNF-α위(6.5±3.2) ng/L、IL-6위(6.7±1.7) ng/L、IL-1 β위(24.3±2.7)ng/L,경도억욱증환자적TNF-α위(39.2±7.4)ng/L、IL-6위(19.8±6.4)ng/L、IL-1β위(42.4±5.6)ng/L,중도억욱증환자적TNF-α위(29.7±5.1) ng/L、IL-6위(9.2±3.1)ng/L、IL-1 β위(31.6±3.1)ng/L,중도억욱증환자혈청세포인자수평여경、중도억욱증환자비교차이유통계학의의(P＜0.05);중도억욱증환자적혈청세포인자수평현저고우경도억욱증환자,차이유통계학의의(P＜0.05);뇌경사후억욱증치료후적혈청세포인자수평[TNF-α(23.4±3.9) ng/L)、IL-6(7.4±2.7) ng/L、IL-1 β(22.4±3.4) ng/L)]현저저우치료전[(TNF-α(32.2±7.5) ng/L)、IL-6(12.9±3.8) ng/L、IL-1[β (40.9±4.6) ng/L)],차이유통계학의의(P＜0.05).결론 혈청세포인자수평여뇌경사후억욱증밀절상관,가직접반영뇌경사후억욱증적병정진전.
Objective To study the correlation between the levels of serum IL-1β,IL-6,and TNF-α and depression after cerebral infarction.Methods 80 patients with depression after cerebral infarction admitted into our hospital from May,2013 to April,2014 were selected as a study group and 80 patients without depression after cerebral infarction a control group.The levels of TNF-α,IL-6,and IL-l β were detected with ELISA examination.Prozac antidepressant drug were taken for 1 month.The levels of TNF-α,IL-6,and IL-1β were compared between these two group.The levels of serum cell factors in patients with different degrees of depression were observed.The levels of serum cell factors were compared between before and after the treatment for depression after cerebral infarction.Results The levels of TNF-α,IL-6,and IL-1β were (32.2±7.5) ng/L,(12.9±3.8) ng/L,and (40.9±4.6) ng/L in the study group and were (19.7±4.1) ng/L,(5.2±2.1)ng/L,and (16.6±3.1) ng/L in the control group,with statistical differences (P ＜0.05).The levels of serum cell factors increased with the degree of depression after cerebral infarction;the levels of serum TNF-α,IL-6,and IL-1β were (6.5±3.2) ng/L,IL-6 (6.7±1.7) ng/L,and (24.3±2.7) ng/L in the patients with severe depression,(39.2±7.4) ng/L,(19.8±6.4) ng/L,and (42.4±5.6) ng/L in the patients with moderate depression,and (29.7±5.l)ng/L,(9.2±3.1)ng/L,and (31.6±3.1)ng/L in the patients with mild depression,with statistical differences between the patients with severe and moderate,between severe and mild,and between moderate and mild depression(P ＜0.05).The levels of serum TNF-α,IL-6,and IL-1β in patiets with depression after cerebral infarction were (23.4±3.9) ng/L,(7.4±2.7) ng/L,and (22.4±3.4)ng/ L after the treatment and were (32.2±7.5) ng/L,(12.9±3.8) ng/L,and (40.9±4.6) ng/L before the treatment,with statistical differences (P ＜0.05).Conclusions The levels of serum cell factors closely correlates with depression after cerebral infarction and can directly reflect the depression's progress.
