CAJ | 학술논문

目的：探讨糖化血红蛋白(HbA1c)、尿微量白蛋白(UmAlb)、尿微量白蛋白/尿肌酐比值(UmAlb/UCr)联合检测在早期糖尿病肾病诊断和治疗中的价值。方法：选取116例糖尿病患者为观察组和86例健康体检者为对照组（N组）分别检测HbA1c,UmAlb,UmAlb/UCr，并对观察组治疗前后及对照组应用统计学方法进行分析。将观察组根据HhAI c的水平分为4组：A组(HbA1c4.8%±1.0%)B组(HhAlc6.5%±0.6%)C组(HbA1c8.1%±1.0%)D组(HhAlc10.1%±1.3%)。结果：糖尿病患者观察组HbA1c,UmAlb,UmAlb/UCr较正常对照组显著升高（P<0.05），随着HbA1c的升高糖尿病患者UmAlb,UmAlb/UCr升高更明显，且三项联合检测阳性率明显高于单项检测阳性率，经治疗后HbA1c,UmAlb,UmAlb/UCr结果显著降低（P<0.05）。结论：HbA1c,UmAlb,UmAlb/UCr联合检测提高了早期糖尿病肾病诊断的敏感性，对于早期糖尿病肾病的诊断和治疗有着非常重要的价值．
목적：탐토당화혈홍단백(HbA1c)、뇨미량백단백(UmAlb)、뇨미량백단백/뇨기항비치(UmAlb/UCr)연합검측재조기당뇨병신병진단화치료중적개치。방법：선취116례당뇨병환자위관찰조화86례건강체검자위대조조（N조）분별검측HbA1c,UmAlb,UmAlb/UCr，병대관찰조치료전후급대조조응용통계학방법진행분석。장관찰조근거HhAI c적수평분위4조：A조(HbA1c4.8%±1.0%)B조(HhAlc6.5%±0.6%)C조(HbA1c8.1%±1.0%)D조(HhAlc10.1%±1.3%)。결과：당뇨병환자관찰조HbA1c,UmAlb,UmAlb/UCr교정상대조조현저승고（P<0.05），수착HbA1c적승고당뇨병환자UmAlb,UmAlb/UCr승고경명현，차삼항연합검측양성솔명현고우단항검측양성솔，경치료후HbA1c,UmAlb,UmAlb/UCr결과현저강저（P<0.05）。결론：HbA1c,UmAlb,UmAlb/UCr연합검측제고료조기당뇨병신병진단적민감성，대우조기당뇨병신병적진단화치료유착비상중요적개치．
Objective:To explore the value of the joint detection of Glycosylated hemoglobin,Urinary Microalbuminuria,Ratio of urinary microalbumin and urinary creatinine for the diagnosis and treatment in Early Diabetic Nephropathy. Methods:Glycosylated hemoglobin,Urinary Microalbuminuria,Ratio of urinary microalbumin and urinary creatinine were detected in 116 patients who have already diagnosed as diabetes. 4 groups were divided by standard of HbA1c (A) 4.8%± 1.0%;(B)6.5%± 0.6%;(C)8.1%± 1.0%;(D) 10.1%± 1.3%.And 86 healthy controls was studied ,meanwhile .the rate of combined detection was analyzed . As 116 patients com-pared with normal controls and 116 patients who were given effect treatment, the levels were detected by immunoturbidimetric assay. Results:The levels of HbA1c,UmAlb,UmAlb/UCr in DM patients were much higher than those of normal controls(P<0.05).As the lev-els of HbA1c increased, the levels of UmAlb,UmAlb/UCr increased significantly. Moreover, the positive rate of combined detection was significantly higher than that of the individual testing (p<0.05). The levels of HbA1c,UmAlb,UmAlb/UCr in 116 DM patients who were given effect treatment were significantly reducted. Conclusions:The combined determination of HbA1c,UmAlb,UmAlb/UCr may improve the sensitivity in the diagnosis of Early Diabetic Nephropathy and has a very important value in diagnosis and treatment of Early Diabetic Nephropathy.