国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
11期
1585-1588
,共4页
陆丽苗%熊流新%梁伟琼%莫善钰%莫毅雄%何莲珠
陸麗苗%熊流新%樑偉瓊%莫善鈺%莫毅雄%何蓮珠
륙려묘%웅류신%량위경%막선옥%막의웅%하련주
性传播疾病%女性%免疫%不孕症
性傳播疾病%女性%免疫%不孕癥
성전파질병%녀성%면역%불잉증
Sexually transmitted diseases%Female%Immune%Infertility%Pathogens
目的 为进一步探讨无症状性传播疾病对女性免疫不孕的影响.方法 从2010年1月开始对766例不孕女性患者和332例已正常生育妇女生殖道分泌物样本常规进行淋球菌和支原体培养、衣原体、涂片找结核杆菌、假丝酵母菌、滴虫等病原体以及用金标法定性检测抗精子抗体、抗卵巢抗体、抗子宫内膜抗体、抗心磷脂抗体及抗绒毛膜促性腺激素抗体检查.结果 无症状性传播疾病病原体以解脲支原体、衣原体和淋球菌为主,阳性率分别为33.68％、18.80％、14.62％,高于对照组的15.66％、12.65％、9.64％,差异有统计学意义(P＜0.05,P＜0.01);无症状性性传播疾病病原体感染组的血液样本检测抗精子抗体、抗卵巢抗体、抗子宫内膜抗体、抗心磷脂抗体及抗绒毛膜促性腺激素抗体的阳性率为高于非感染组的,差异有统计学意义(P＜0.05,P＜0.01);继发不孕患者中检测出上述五种抗体阳性比率高于原发不孕患者.结论 性传播疾病主要病原体为以UU、CT、NG为主,病原体引起女性泌尿生殖道感染后容易诱发机体产生抗精子抗体、抗卵巢抗体、抗子宫内膜抗体、抗心磷脂抗体;分娩、妇科手术可增加性传播性疾病发生的危险性,也是诱发女性免疫性不孕症的重要因素.
目的 為進一步探討無癥狀性傳播疾病對女性免疫不孕的影響.方法 從2010年1月開始對766例不孕女性患者和332例已正常生育婦女生殖道分泌物樣本常規進行淋毬菌和支原體培養、衣原體、塗片找結覈桿菌、假絲酵母菌、滴蟲等病原體以及用金標法定性檢測抗精子抗體、抗卵巢抗體、抗子宮內膜抗體、抗心燐脂抗體及抗絨毛膜促性腺激素抗體檢查.結果 無癥狀性傳播疾病病原體以解脲支原體、衣原體和淋毬菌為主,暘性率分彆為33.68％、18.80％、14.62％,高于對照組的15.66％、12.65％、9.64％,差異有統計學意義(P＜0.05,P＜0.01);無癥狀性性傳播疾病病原體感染組的血液樣本檢測抗精子抗體、抗卵巢抗體、抗子宮內膜抗體、抗心燐脂抗體及抗絨毛膜促性腺激素抗體的暘性率為高于非感染組的,差異有統計學意義(P＜0.05,P＜0.01);繼髮不孕患者中檢測齣上述五種抗體暘性比率高于原髮不孕患者.結論 性傳播疾病主要病原體為以UU、CT、NG為主,病原體引起女性泌尿生殖道感染後容易誘髮機體產生抗精子抗體、抗卵巢抗體、抗子宮內膜抗體、抗心燐脂抗體;分娩、婦科手術可增加性傳播性疾病髮生的危險性,也是誘髮女性免疫性不孕癥的重要因素.
목적 위진일보탐토무증상성전파질병대녀성면역불잉적영향.방법 종2010년1월개시대766례불잉녀성환자화332례이정상생육부녀생식도분비물양본상규진행림구균화지원체배양、의원체、도편조결핵간균、가사효모균、적충등병원체이급용금표법정성검측항정자항체、항란소항체、항자궁내막항체、항심린지항체급항융모막촉성선격소항체검사.결과 무증상성전파질병병원체이해뇨지원체、의원체화림구균위주,양성솔분별위33.68％、18.80％、14.62％,고우대조조적15.66％、12.65％、9.64％,차이유통계학의의(P＜0.05,P＜0.01);무증상성성전파질병병원체감염조적혈액양본검측항정자항체、항란소항체、항자궁내막항체、항심린지항체급항융모막촉성선격소항체적양성솔위고우비감염조적,차이유통계학의의(P＜0.05,P＜0.01);계발불잉환자중검측출상술오충항체양성비솔고우원발불잉환자.결론 성전파질병주요병원체위이UU、CT、NG위주,병원체인기녀성비뇨생식도감염후용역유발궤체산생항정자항체、항란소항체、항자궁내막항체、항심린지항체;분면、부과수술가증가성전파성질병발생적위험성,야시유발녀성면역성불잉증적중요인소.
Objective To investigate the impact of asymptomatic sexually transmitted diseases on female immune infertility.Methods From January,2010,766 infertile women and 332 normal fertile women were retrospectively analyzed.Their secretion samples from the genital tracts were cultured to detect neisseria gonorrhoeae,chlamydia,mycoplasma routine,and smear to detect mycobacterium tuberculosis,candida,trichomonas,and other pathogens.Colloidal gold was used to detect serum anti-sperm antibody,anti-ovary antibody,anti-endometrial antibody,anti-cardiolipin antibody,and anti-human chorionic gonadotropin.The results were statistically analyzed.Results The main pathogens of asymptomatic sexually transmitted disease were neisseria gonorrhoeae,chlamydia trachomatis,and ureaplasma urealyticum,whose positive rates were 33.68％ and 14.62％,which were higher than the control group's (15.66％,12.65％,9.64％),with statistical differences (P ＜ 0.05,P ＜ 0.01).The positive rates of anti-sperm antibody,anti-ovary antibody,anti-endometrial antibody,anti-cardiolipin antibody,and anti-hCG antibody were higher in the asymptomatic infection pathogens of sexually transmitted disease group than in the non-infection group,with statistical differences (P ＜ 0.05,P ＜ 0.01),and were higher in the patients with secondary than primary infertility.Conclusions The main pathogens sexually transmitted diseases are UU,CT,and NG.The production of anti-sperm antibody,anti-ovary antibody,anti-endometrial antibody,and anti-cardiolipin antibody is easily induced the infection of female urogenital tract.Delivering and gynecological operation can increase the incidence of sexually transmitted diseases and increase the risk of immune antibody production and are factors causing female immune infertility.
