CAJ | 학술논문

目的：探讨脑钠肽（ BNP）在慢性阻塞性肺疾病（ COPD）患者中检测的临床意义。方法选择2012年8月至2013年8月收治的COPD患者80例，按病情分为急性加重期为40例，稳定期患者40例。同时选择健康患者40例作为对照组。所有参与研究的对象均空腹抽取2 ml静脉血，检测血浆BNP水平。观察COPD患者与对照组、COPD患者治疗前后BNP水平的差异。结果 COPD患者BNP水平明显高于对照组，而急性加重期患者又明显高于稳定期患者，三组比较差异具有统计学意义（ P <0.05）。COPD患者治疗1 d 和治疗7 d后，血浆BNP水平较治疗前明显下降，治疗7 d后又比治疗1 d时明显下降，差异均有统计学意义（ P <0.05）。急性加重期患者治疗前血浆BNP平均值为176.5±28.7 pg/ml，有18例重度患者转入ICU行机械通气治疗，18例重度患者血浆BNP平均值为351.8±57.3 pg/ml，明显高于急性加重期患者的平均水平，差异具有统计学意义（ P <0.05）。结论血浆BNP水平在COPD患者急性加重期、稳定期均有不同程度的升高，其与COPD的严重程度具有密切相关性。
목적：탐토뇌납태（ BNP）재만성조새성폐질병（ COPD）환자중검측적림상의의。방법선택2012년8월지2013년8월수치적COPD환자80례，안병정분위급성가중기위40례，은정기환자40례。동시선택건강환자40례작위대조조。소유삼여연구적대상균공복추취2 ml정맥혈，검측혈장BNP수평。관찰COPD환자여대조조、COPD환자치료전후BNP수평적차이。결과 COPD환자BNP수평명현고우대조조，이급성가중기환자우명현고우은정기환자，삼조비교차이구유통계학의의（ P <0.05）。COPD환자치료1 d 화치료7 d후，혈장BNP수평교치료전명현하강，치료7 d후우비치료1 d시명현하강，차이균유통계학의의（ P <0.05）。급성가중기환자치료전혈장BNP평균치위176.5±28.7 pg/ml，유18례중도환자전입ICU행궤계통기치료，18례중도환자혈장BNP평균치위351.8±57.3 pg/ml，명현고우급성가중기환자적평균수평，차이구유통계학의의（ P <0.05）。결론혈장BNP수평재COPD환자급성가중기、은정기균유불동정도적승고，기여COPD적엄중정도구유밀절상관성。
Objective To assess the clinical significance of brain natriuretic peptide( BNP)in patients with chronic obstructive pulmona-ry disease( COPD). Methods Eighty COPD patients treated in our hospital from Aug 2012 to Aug 2013 were divided into 2 groups according to the stage of disease. Forty patients with acute exacerbation of COPD and 40 patients with stable COPD were enrolled in the study. Forty healthy subjects were as control. The serum BNP levels were determined and compared among groups and before and after treatment. Results Serum BNP level in COPD patients was significantly higher than that in control group,and it was higher in acute COPD than that in stable COPD,there was significant difference in BNP level among three groups( P <0. 05). BNP level was decreased after treatment and it was further decreased after 7days of treatment in comparison with the value of one day treatment( P <0. 05). The mean BNP in 18 cases of severe COPD who received me-chanical ventilation in ICU(351. 8 ± 57. 3 pg/ml)was significantly higher than that in acute exacerbation COPD patients( P <0. 05). Conclu-sion Serum BNP levels increase at different degrees in both acute exacerbation and stable COPD,and it closely relates to the severity of COPD.