临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
16期
25-27
,共3页
慢性阻塞性肺疾病%糖皮质激素%血气分析%血糖%pH值
慢性阻塞性肺疾病%糖皮質激素%血氣分析%血糖%pH值
만성조새성폐질병%당피질격소%혈기분석%혈당%pH치
Chronic obstructive pulmonary disease%Glucocorticoid%Blood gas analyzes%Glucose%pH value
目的：比较全身使用激素及雾化吸入激素治疗COPD急性加重期（ AECOPD）对血气分析分压及血糖影响的差异。方法将178例AECOPD患者随机分为观察组和对照组各89例。观察组给予布地奈德雾化吸入治疗，对照组给予甲泼尼龙静脉注射治疗。比较2组治疗前后的动脉血氧分压（ PaO2）、动脉血二氧化碳分压（ PaCO2）、pH值及空腹血糖水平。结果治疗后观察组PaO2高于治疗前，PaCO2低于治疗前，差异均有统计学意义（P＜0．01）。观察组治疗前后pH值及空腹血糖比较差异无统计学意义（P＞0．05）。治疗后对照组PaO2高于治疗前，空腹血糖高于治疗前，差异均有统计学意义（P＜0．05）。对照组治疗前后PaCO2及pH值比较差异无统计学意义（P＞0．05）。结论对于AECOPD患者局部吸入激素疗效优于全身用药，不良反应少。
目的：比較全身使用激素及霧化吸入激素治療COPD急性加重期（ AECOPD）對血氣分析分壓及血糖影響的差異。方法將178例AECOPD患者隨機分為觀察組和對照組各89例。觀察組給予佈地奈德霧化吸入治療，對照組給予甲潑尼龍靜脈註射治療。比較2組治療前後的動脈血氧分壓（ PaO2）、動脈血二氧化碳分壓（ PaCO2）、pH值及空腹血糖水平。結果治療後觀察組PaO2高于治療前，PaCO2低于治療前，差異均有統計學意義（P＜0．01）。觀察組治療前後pH值及空腹血糖比較差異無統計學意義（P＞0．05）。治療後對照組PaO2高于治療前，空腹血糖高于治療前，差異均有統計學意義（P＜0．05）。對照組治療前後PaCO2及pH值比較差異無統計學意義（P＞0．05）。結論對于AECOPD患者跼部吸入激素療效優于全身用藥，不良反應少。
목적：비교전신사용격소급무화흡입격소치료COPD급성가중기（ AECOPD）대혈기분석분압급혈당영향적차이。방법장178례AECOPD환자수궤분위관찰조화대조조각89례。관찰조급여포지내덕무화흡입치료，대조조급여갑발니룡정맥주사치료。비교2조치료전후적동맥혈양분압（ PaO2）、동맥혈이양화탄분압（ PaCO2）、pH치급공복혈당수평。결과치료후관찰조PaO2고우치료전，PaCO2저우치료전，차이균유통계학의의（P＜0．01）。관찰조치료전후pH치급공복혈당비교차이무통계학의의（P＞0．05）。치료후대조조PaO2고우치료전，공복혈당고우치료전，차이균유통계학의의（P＜0．05）。대조조치료전후PaCO2급pH치비교차이무통계학의의（P＞0．05）。결론대우AECOPD환자국부흡입격소료효우우전신용약，불량반응소。
Objective To compare the blood points off change and blood glucose affect of systemic steroids and hor -mone therapy atomization for acute exacerbation of COPD (AECOPD).Methods 178 patients with AECOPD were randomly divided into observation group and control group ,each of 89 cases.Observation group received budesonide inhalation therapy , control group was given intravenous methylprednisolone therapy .Compared the oxygen tension (PaO2),arterial carbon dioxide (PaCO2),pH value and fasting glucose levels before and after treatment of two groups .Results After treatment,the PaO2 of observation group was higher than that before treatment ,the PaCO2 of observation group was lower than that before treatment , the differences were statistically significant (P<0.01).The difference of pH value and the fasting blood glucose before and af-ter treatment of observation group were not statistically significant (P>0.05).After treatment the PaO2 of control group was higher than before treatment ,fasting blood glucose was higher than before treatment ,the differences were statistically significant (P<0.05).The difference of PaCO2 and pH value of control group before and after treatment were not statistically significant (P>0.05).Conclusion In patients with AECOPD,local inhaled corticosteroid treatment is better than that of systemic med-ication,and less side effects .
