临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
16期
1-2
,共2页
葛根素%口腔崩解片%冷冻干燥法%沉降容积%崩解时间
葛根素%口腔崩解片%冷凍榦燥法%沉降容積%崩解時間
갈근소%구강붕해편%냉동간조법%침강용적%붕해시간
Puerarin%Orally disintegrating tablets%Lyopyilization%Sedimentation volume%Disintegration time
目的：以葛根素为模型药物制备口腔崩解片。方法该研制把崩解时间及沉降容积比为指标，单因素法筛选片剂的处方组成及工艺，并优化制备工艺。结果葛根素口腔崩解片的辅料为甘露醇、明胶、阿司帕坦与薄荷香精，经过冷冻干燥方法制备，口感良好，4s的崩解时间，在4min内体外溶出度达96．46％。结论葛根素口腔崩解片可迅速崩解于口腔内，制备工艺可行。
目的：以葛根素為模型藥物製備口腔崩解片。方法該研製把崩解時間及沉降容積比為指標，單因素法篩選片劑的處方組成及工藝，併優化製備工藝。結果葛根素口腔崩解片的輔料為甘露醇、明膠、阿司帕坦與薄荷香精，經過冷凍榦燥方法製備，口感良好，4s的崩解時間，在4min內體外溶齣度達96．46％。結論葛根素口腔崩解片可迅速崩解于口腔內，製備工藝可行。
목적：이갈근소위모형약물제비구강붕해편。방법해연제파붕해시간급침강용적비위지표，단인소법사선편제적처방조성급공예，병우화제비공예。결과갈근소구강붕해편적보료위감로순、명효、아사파탄여박하향정，경과냉동간조방법제비，구감량호，4s적붕해시간，재4min내체외용출도체96．46％。결론갈근소구강붕해편가신속붕해우구강내，제비공예가행。
Objective To develop oral disintegrating tablets with puerarin as themodeldrug .Methods The develop-ment selected the disintegration time and sedimentation volume ratio as an indicator .Screened tablet formulation consisting and process of single factor method .Optimized the preparation process .Results Puerarin orally disintegrating tablets were pre-pared by lyopyilization,containing the inactive ingredient:mannitol,gelatin,aspartame and mint flavor.The prepared tablets tas-ted fine and could disintegrate in 4s.The in vitro dissolution test indicated that 96.46%of puerarin dissolved in 4 minutes from the oral disintegrating tablets .Conclusion The prepared of puerarin oral disintegrating tablets disintegrated rapidly in oral cavity,the process of preparation is feasible .
