安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2015年
6期
1091-1094
,共4页
杨宁%胡立群%李红旗%章琦
楊寧%鬍立群%李紅旂%章琦
양저%호립군%리홍기%장기
高密度脂蛋白亚类%冠状动脉造影%Gensini评分
高密度脂蛋白亞類%冠狀動脈造影%Gensini評分
고밀도지단백아류%관상동맥조영%Gensini평분
high-density lipoprotein(HDL)subclasses%coronary arteriography%gensini score
目的：探讨冠脉造影患者高密度脂蛋白（high-density lipoprotein，HDL）亚类对冠状动脉狭窄程度影响的相关性。方法（1）抽取2013—2014年因疑诊冠心病（coronary heart disease，CHD）入住该院老年医学科、心内科行冠状动脉造影（coronary arteriography，CAG）的患者122例，经选择性冠状动脉造影确诊为CHD患者（至少有一支冠状动脉或分支狭窄＞50％）96例，其中男62例，女34例，平均年龄（60．31±8．72）岁，未诊断CHD患者26例，男10例，女16例，平均年龄（59．00±13．51）岁；（2）抽取患者空腹12 h静脉血，选择双向电泳—免疫印迹检测法24 h内测定HDL亚类，对患者冠脉造影结果（采用Gensini评分）评价冠状动脉狭窄程度；（3）计量资料用均数±标准差（x ±s）表示，定性资料用χ2检验，两组比较采用独立样本的t检验， Logisitic回归分析检验与冠心病相关因素，两因素相关性采用线性相关分析。结果（1）单因素卡方、两样本独立t检验显示性别、吸烟史、糖尿病史、收缩压、体质指数（body mass index，BMI）、腰围（waist circumference，WC）、腰臀比（waist to hip ratio， WHR）、HDL、LDL、ApoA-I 、Lpa、Preβ1-HDL、HDL3b、HDL3c、HDL2b与冠心病有关，差异有统计学意义（P＜0．05）；（2）TG、Preβ1-HDL、HDL3b是冠心病危险因素，HDL2b是冠心病保护因素（P＜0．05）；（3）HDL2b与Gensini评分结果成负相关，Preβ1-HDL、HDL3b与Gensini评分结果成正相关。结论在临床诊断治疗中，HDL2b值有可能做为冠心病预测因素，Preβ1-HDL、HDL3b值可为预测和诊断CHD提供重要依据，冠心病的防治不仅要改善和促进胆固醇逆转运还要调节血脂，调整HDL亚类的构成比。
目的：探討冠脈造影患者高密度脂蛋白（high-density lipoprotein，HDL）亞類對冠狀動脈狹窄程度影響的相關性。方法（1）抽取2013—2014年因疑診冠心病（coronary heart disease，CHD）入住該院老年醫學科、心內科行冠狀動脈造影（coronary arteriography，CAG）的患者122例，經選擇性冠狀動脈造影確診為CHD患者（至少有一支冠狀動脈或分支狹窄＞50％）96例，其中男62例，女34例，平均年齡（60．31±8．72）歲，未診斷CHD患者26例，男10例，女16例，平均年齡（59．00±13．51）歲；（2）抽取患者空腹12 h靜脈血，選擇雙嚮電泳—免疫印跡檢測法24 h內測定HDL亞類，對患者冠脈造影結果（採用Gensini評分）評價冠狀動脈狹窄程度；（3）計量資料用均數±標準差（x ±s）錶示，定性資料用χ2檢驗，兩組比較採用獨立樣本的t檢驗， Logisitic迴歸分析檢驗與冠心病相關因素，兩因素相關性採用線性相關分析。結果（1）單因素卡方、兩樣本獨立t檢驗顯示性彆、吸煙史、糖尿病史、收縮壓、體質指數（body mass index，BMI）、腰圍（waist circumference，WC）、腰臀比（waist to hip ratio， WHR）、HDL、LDL、ApoA-I 、Lpa、Preβ1-HDL、HDL3b、HDL3c、HDL2b與冠心病有關，差異有統計學意義（P＜0．05）；（2）TG、Preβ1-HDL、HDL3b是冠心病危險因素，HDL2b是冠心病保護因素（P＜0．05）；（3）HDL2b與Gensini評分結果成負相關，Preβ1-HDL、HDL3b與Gensini評分結果成正相關。結論在臨床診斷治療中，HDL2b值有可能做為冠心病預測因素，Preβ1-HDL、HDL3b值可為預測和診斷CHD提供重要依據，冠心病的防治不僅要改善和促進膽固醇逆轉運還要調節血脂，調整HDL亞類的構成比。
목적：탐토관맥조영환자고밀도지단백（high-density lipoprotein，HDL）아류대관상동맥협착정도영향적상관성。방법（1）추취2013—2014년인의진관심병（coronary heart disease，CHD）입주해원노년의학과、심내과행관상동맥조영（coronary arteriography，CAG）적환자122례，경선택성관상동맥조영학진위CHD환자（지소유일지관상동맥혹분지협착＞50％）96례，기중남62례，녀34례，평균년령（60．31±8．72）세，미진단CHD환자26례，남10례，녀16례，평균년령（59．00±13．51）세；（2）추취환자공복12 h정맥혈，선택쌍향전영—면역인적검측법24 h내측정HDL아류，대환자관맥조영결과（채용Gensini평분）평개관상동맥협착정도；（3）계량자료용균수±표준차（x ±s）표시，정성자료용χ2검험，량조비교채용독립양본적t검험， Logisitic회귀분석검험여관심병상관인소，량인소상관성채용선성상관분석。결과（1）단인소잡방、량양본독립t검험현시성별、흡연사、당뇨병사、수축압、체질지수（body mass index，BMI）、요위（waist circumference，WC）、요둔비（waist to hip ratio， WHR）、HDL、LDL、ApoA-I 、Lpa、Preβ1-HDL、HDL3b、HDL3c、HDL2b여관심병유관，차이유통계학의의（P＜0．05）；（2）TG、Preβ1-HDL、HDL3b시관심병위험인소，HDL2b시관심병보호인소（P＜0．05）；（3）HDL2b여Gensini평분결과성부상관，Preβ1-HDL、HDL3b여Gensini평분결과성정상관。결론재림상진단치료중，HDL2b치유가능주위관심병예측인소，Preβ1-HDL、HDL3b치가위예측화진단CHD제공중요의거，관심병적방치불부요개선화촉진담고순역전운환요조절혈지，조정HDL아류적구성비。
Objective To investigate the relationship of high-density lipoprotein(HDL)subclasses with severity of coronary artery steno-sis in patients with Coronary angiography.Methods (1)A total of 122 consecutive patients underwent Coronary angiography were se-lected,because of suspected diagnosis of CHD was admitted to Gerontology Department,Vasculocardiology Department from 2013 to 2014 in our hospital,The confirmed diagnosis of CHD patients (At least have a coronary artery or branch stenosis>50%)96,62 males and 34 females,with an average of (60.31 ±8.72)years old,normal CAG findings patients 26,10 males and 16 females,with an aver-age of(59.00 ±13.51)years old;(2)Extraction in patients with venous blood fasting 12 hours,The contents of serum HDL subclasses were determined by two dimensional gel electrophoresis associated with immunodetection method within 24 hours.Through the evalua-tion of the results of coronary angiography in patients with coronary artery stenosis degree(by Gensini score);(3).measurement data with mean ±standard deviation (x ±s)and the qualitative data withχ2 test,Comparing the two groups using independent sample t test, Using logisitic regression test and coronary heart disease (CHD)related factors,The correlation between two factors using linear corre-lation analysis.Results (1 )Single factor chi-square,two independent samples t test showed that sex,smoking history,history of diabe-tes mellitus,systolic blood pressure,BMI,WC,WHR,HDL,LDL,ApoA-I,Lpa,Preβ1-HDL,HDL3b ,HDL3c ,HDL2b associated with coro-nary heart disease (CHD),The difference was statistically significant.(2)Smoking,systolic blood pressure,TG,Preβ1-HDL,HDL3b, HDL3c is coronary heart disease risk factors,HDL2b is coronary heart disease (CHD)protection factor.(3)HDL2b negative correlation with Gensini score,Preβ1- HDL,HDL3b are positively related with Gensini score.Conclusion In the clinical diagnosis and treatment, HDL2b possible as predictors for coronary heart disease,Preβ1-HDL,HDL3b numerical can provide important basis for prediction and di-agnosis of CHD,Coronary heart disease prevention is not only to improve and promote reverse cholesterol transport and regulating blood fat,but also regulate the HDL subclasses and their constituent ratio.
