CAJ | 학술논문

目的：观察早期冠状动脉内支架植入术与延迟支架植入术治疗不稳定型心绞痛的临床效果。方法选择我院收治的80例不稳定型心绞痛患者为研究对象，随机分为对照组和观察组各40例。对照组入院后7~10 d行支架术，观察组入院后48 h内行支架术。比较两组患者的手术成功率、再狭窄发生率及治疗前后冠状静脉窦NO水平变化情况。结果观察组手术成功率(92.5%)明显高于对照组(75.0%)，随访再狭窄发生率(2.5%)明显低于对照组(20.0%)，观察组术后即刻及术后6 h的NO水平分别为(54.2±12.3)μmol/L和(70.5±13.5)μmol/L，均明显低于对照组的(84.6±13.1)μmol/L和(93.6±12.8)μmol/L，以上各项指标比较差异均有统计学意义(P<0.05)。结论选择早期冠状动脉内支架植入术治疗不稳定型心绞痛成功率高，再狭窄发生率低，治疗后冠状静脉窦NO水平下降显著，值得临床推广应用。
목적：관찰조기관상동맥내지가식입술여연지지가식입술치료불은정형심교통적림상효과。방법선택아원수치적80례불은정형심교통환자위연구대상，수궤분위대조조화관찰조각40례。대조조입원후7~10 d행지가술，관찰조입원후48 h내행지가술。비교량조환자적수술성공솔、재협착발생솔급치료전후관상정맥두NO수평변화정황。결과관찰조수술성공솔(92.5%)명현고우대조조(75.0%)，수방재협착발생솔(2.5%)명현저우대조조(20.0%)，관찰조술후즉각급술후6 h적NO수평분별위(54.2±12.3)μmol/L화(70.5±13.5)μmol/L，균명현저우대조조적(84.6±13.1)μmol/L화(93.6±12.8)μmol/L，이상각항지표비교차이균유통계학의의(P<0.05)。결론선택조기관상동맥내지가식입술치료불은정형심교통성공솔고，재협착발생솔저，치료후관상정맥두NO수평하강현저，치득림상추엄응용。
Objective To observe the clinical effect of early coronary artery stent implantation and de-layed coronary artery stent implantation for treatment of unstable angina. Methods Eighty patients of unstable angina in our hospital were selected as the research objects, which were randomly divided into control group and observation group, with 40 patients in each group. The control group received coronary artery stent implantation 7~10 d after admission, while the observation group underwent coronary artery stent implantation in 48 hours af-ter admission. The surgical success rate, incidence of restenosis, and level of NO in coronary sinus before and af-ter treatment were compared between the two groups. Results The surgical success rate in the observation group (92.5%) was significantly higher than that in the control group (75.0%), and the incidence of restenosis in the ob-servation group was significantly lower (2.5%vs 20.0%). NO level immediately after surgery (54.2±12.3) μmol/L and postoperative 6 hours (70.5±13.5) μmol/L in the observation group were significantly lower than those in the control group, (84.6 ± 13.1) μmol/L and (93.6 ± 12.8) μmol/L, P<0.05. Conclusion Early coronary artery stent im-plantation in the treatment of unstable angina results in high success rate, low incidence of restenosis, significantly de-creased NO level in coronary sinus after treatment, which is worthy of clinical popularization and application.