CAJ | 학술논문

低氧及低氧诱导因子（HIFs）是肿瘤干细胞、转移起始细胞及其分化后代在肿瘤发生发展过程中，能够适应氧气和营养物质缺乏的主要调节因子。在白血病、胶质母细胞瘤、黑色素瘤、前列腺癌、乳腺癌、胰腺癌等肿瘤中均发现HIFs的表达上调，尤其集中表达在低氧区域。活化的HIFs可以诱导多种干性及多药耐药等基因的表达，对肿瘤及干性介导的肿瘤细胞的自我更新、能量代谢改变、侵袭转移、血管生成以及治疗抵抗均起着重要作用。因此，研究HIFs分子在干细胞介导的不同肿瘤细胞中的靶向调节作用和代谢通路的改变，将为肿瘤的靶向治疗提供新线索。
저양급저양유도인자（HIFs）시종류간세포、전이기시세포급기분화후대재종류발생발전과정중，능구괄응양기화영양물질결핍적주요조절인자。재백혈병、효질모세포류、흑색소류、전렬선암、유선암、이선암등종류중균발현HIFs적표체상조，우기집중표체재저양구역。활화적HIFs가이유도다충간성급다약내약등기인적표체，대종류급간성개도적종류세포적자아경신、능량대사개변、침습전이、혈관생성이급치료저항균기착중요작용。인차，연구HIFs분자재간세포개도적불동종류세포중적파향조절작용화대사통로적개변，장위종류적파향치료제공신선색。
Hypoxia and hypoxia-induced factors (HIFs) are main regulators for tumor stem cells, metastasis-initiating cells and their differentiated progenies to adapt to the environment which lacks oxygen and nutrient in the process of cancer development. HIFs are up-regulated in many tumors, including leukemia, glioblastoma, melanoma, prostate cancer, breast cancer and pancreatic cancer, in where they are especially highly expressed in hypoxic regions. HIFs activation can induce expression of numerous stem cell related genes and multidrug resistance genes, which may play important roles in tumour and stem cell-mediated self-renewing, energy metabolism alternation, invasion, metastasis, angiogenesis and treatment resis?tance of neoplastic cells. Consequently, it will provide new clues for cancer therapy after investigating the role of HIFs in tar?geted regulation and metabolic pathway modulation in various stem cell-mediated tumor cells.