CAJ | 학술논문

目的：观察氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病（ CLL）的疗效和安全性。方法：将CLL患者40例随机分为治疗组和对照组，各20例。治疗组予以氟达拉滨联合环磷酰胺方案治疗，对照组予以CHOP方案化疗，比较两组总有效率及不良反应。结果：治疗组总有效率为90.00％，高于对照组的60.00％，两组比较差异有统计学意义（P＜0.05）；两组胃肠道反应、感染及骨髓抑制发生率比较，差异无统计学意义（P＞0.05）。结论：氟达拉滨联合环磷酰胺组治疗CLL具有完全缓解率及总有效率高、不良反应轻等优点。
목적：관찰불체랍빈연합배린선알치료만성림파세포백혈병（ CLL）적료효화안전성。방법：장CLL환자40례수궤분위치료조화대조조，각20례。치료조여이불체랍빈연합배린선알방안치료，대조조여이CHOP방안화료，비교량조총유효솔급불량반응。결과：치료조총유효솔위90.00％，고우대조조적60.00％，량조비교차이유통계학의의（P＜0.05）；량조위장도반응、감염급골수억제발생솔비교，차이무통계학의의（P＞0.05）。결론：불체랍빈연합배린선알조치료CLL구유완전완해솔급총유효솔고、불량반응경등우점。
Objective:To observe the efficacy and safety of fludarabine combined with cyclophosphamide in chronic lym-phocytic leukemia( CLL). Methods:Forty cases of patients diagnosed CLL were randomly divided into treatment group and con-trol group,each of 20 cases. Treatment group was given fludarabine combined with cyclophosphamide. Control group was treated with CHOP regimen. To compare the total efficiency rate and adverse reactions of two groups. Results:The total effective rate of teatment group( 9 0 . 0 0%)was higher than that of control group( 6 0 . 0 0% ),the difference was statistically significant( P <0. 05). There was no statistical difference(P>0. 05)between two groups in rates of gastrointestinal tract reaction,infection and the incidence of bone marrow suppression. Conclusion:Fludarabine combined with cyclophosphamide in CLL has a much better effect and less toxic side effect.