CAJ | 학술논문

目的：探讨重组改构人肿瘤坏死因子（ rmhTNF）对恶性胸/腹腔积液的治疗作用。方法：观察56例恶性胸/腹腔积液的患者，随机分为TNF组（用rmhTNF胸/腹腔内注入治疗）和DDP组（用顺铂胸/腹腔内注入治疗），观察两组疗效、生存质量变化及不良反应情况。结果：TNF组总有效率明显高于DDP组（P＜0.05）；TNF组生存质量改善率明显高于DDP组（P＜0.05）；TNF组的不良反应发生率明显低于DDP组。结论：rmhTNF具有显著的消除胸/腹腔积液的作用，疗效明显优于DDP。
목적：탐토중조개구인종류배사인자（ rmhTNF）대악성흉/복강적액적치료작용。방법：관찰56례악성흉/복강적액적환자，수궤분위TNF조（용rmhTNF흉/복강내주입치료）화DDP조（용순박흉/복강내주입치료），관찰량조료효、생존질량변화급불량반응정황。결과：TNF조총유효솔명현고우DDP조（P＜0.05）；TNF조생존질량개선솔명현고우DDP조（P＜0.05）；TNF조적불량반응발생솔명현저우DDP조。결론：rmhTNF구유현저적소제흉/복강적액적작용，료효명현우우DDP。
Objective:Toinvestigatetheclinicaleffectandadverseofrecombinanthumantumornecrosisfactor(rmhTNF) for malignant pleural/peritoneal effusion. Methods:Fifty-six patients with malignant pleural/peritoneal effusion were enrolled and randomly divided into two groups. Group TNF was infused with rmhTNF,the another one was infused with cisplatin ( DDP). The effective rate,quality of life and adverse reaction were observed. Results:The total effective rate of TNF group was 89. 3%,while it was 64. 3% in DDP group. There was a significant difference between two groups(P<0. 05). The improve-ment rate of KPS in group TNF was 85. 7%,while it was 56. 7% in DDP group. There was a significant difference between two groups(P<0. 05). The adverse reaction rate of TNF group was significantly smaller than DDP group. Conclusion:The rmhTNF is more effective and response quickly with less adverse reaction for treatment of malignant pleural/peritoneal effusion.