医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2015年
5期
964-966
,共3页
小麦/治疗应用%纤维素/治疗应用%有益菌种/治疗应用%便秘/药物疗法%儿童
小麥/治療應用%纖維素/治療應用%有益菌種/治療應用%便祕/藥物療法%兒童
소맥/치료응용%섬유소/치료응용%유익균충/치료응용%편비/약물요법%인동
TRITICUM AESTIVUM/TU%Cellulose/TU%Probiotics/TU%Constipation/DT%Child
【目的】探讨小麦纤维素联合枯草杆菌二联活菌治疗儿童功能性便秘（functional constipation ，FC）的临床疗效。【方法】选取85例门诊FC患儿，随机分为观察组（42例）和对照组（43例）。对照组早晚口服枯草杆菌二联活菌颗粒，观察组在对照组基础上加用小麦纤维素颗粒早晚口服，均以7d为1个疗程，连续治疗3个疗程，观察两组近期临床疗效及显效患儿随访3个月内的复发率。【结果】治疗结束时，观察组显效率显著优于对照组（92．86％ v s 69．77％）（χ2＝7．43， P ＜0．01），但两组总有效率无统计学差异（100％ v s 97．67％）（χ2＝0．97，P＞0．05）；观察组显效患儿随访3个月内的复发率显著低于对照组，差异有统计学意义（2．56％ vs 16．67％）（χ2＝4．24，P＜0．05）。【结论】小麦纤维素联合枯草杆菌二联活菌治疗FC临床疗效确切，在显著改善患儿便秘症状的同时降低了复发率，值得临床推广应用。
【目的】探討小麥纖維素聯閤枯草桿菌二聯活菌治療兒童功能性便祕（functional constipation ，FC）的臨床療效。【方法】選取85例門診FC患兒，隨機分為觀察組（42例）和對照組（43例）。對照組早晚口服枯草桿菌二聯活菌顆粒，觀察組在對照組基礎上加用小麥纖維素顆粒早晚口服，均以7d為1箇療程，連續治療3箇療程，觀察兩組近期臨床療效及顯效患兒隨訪3箇月內的複髮率。【結果】治療結束時，觀察組顯效率顯著優于對照組（92．86％ v s 69．77％）（χ2＝7．43， P ＜0．01），但兩組總有效率無統計學差異（100％ v s 97．67％）（χ2＝0．97，P＞0．05）；觀察組顯效患兒隨訪3箇月內的複髮率顯著低于對照組，差異有統計學意義（2．56％ vs 16．67％）（χ2＝4．24，P＜0．05）。【結論】小麥纖維素聯閤枯草桿菌二聯活菌治療FC臨床療效確切，在顯著改善患兒便祕癥狀的同時降低瞭複髮率，值得臨床推廣應用。
【목적】탐토소맥섬유소연합고초간균이련활균치료인동공능성편비（functional constipation ，FC）적림상료효。【방법】선취85례문진FC환인，수궤분위관찰조（42례）화대조조（43례）。대조조조만구복고초간균이련활균과립，관찰조재대조조기출상가용소맥섬유소과립조만구복，균이7d위1개료정，련속치료3개료정，관찰량조근기림상료효급현효환인수방3개월내적복발솔。【결과】치료결속시，관찰조현효솔현저우우대조조（92．86％ v s 69．77％）（χ2＝7．43， P ＜0．01），단량조총유효솔무통계학차이（100％ v s 97．67％）（χ2＝0．97，P＞0．05）；관찰조현효환인수방3개월내적복발솔현저저우대조조，차이유통계학의의（2．56％ vs 16．67％）（χ2＝4．24，P＜0．05）。【결론】소맥섬유소연합고초간균이련활균치료FC림상료효학절，재현저개선환인편비증상적동시강저료복발솔，치득림상추엄응용。
[Objective] To explore the clinical efficacy and safety of wheat cellulose plus bacillus subtilis duplex living bacterium in the treatment of functional constipation (FC) in children .[Methods] A total of 85 children with FC were randomly divided into treatment (n=42) and control (n=43) groups .The treatment group received bacillus subtilis duplex living bacterium cellulose particles and wheat cellulose while the control group had bacillus subtilis duplex living bacterium cellulose particles alone .Both groups received 3 continuous courses of 7 days each .The recent clinical efficacy ,safety and recurrence rate were observed for 3 months .[Results] At the end of treatment ,the number of marked improvement was significantly more in treatment group than that that in control group (χ2 =7 .43 ,P<0 .01) .But no inter‐group statistical difference existed in overall effective rate (χ2 =0 .97 ,P >0 .05) .And no statistically significant difference existed in safety (χ2 =2 .01 ,P>0 .05) .The inter‐group difference was statistically significant in recurrence rate after a 3‐month fol‐low‐up (χ2 =4 .24 ,P <0 .05) .[Conclusion]Wheat cellulose plus bacillus subtilis duplex living bacterium can significantly improve the constipation symptoms and reduce the recurrence rate in children with FC .With a definite efficacy ,such a regimen is worthy of wider clinical popularization .
