CAJ | 학술논문

目的：：观察百令胶囊联合羟苯磺酸钙分散片治疗糖尿病肾病Ⅳ期,对患者血糖、血脂,肾功能等指标的影响。方法：216例糖尿病肾病Ⅳ期患者随机分为两组各108例。对照组在常规治疗基础上加服羟苯磺酸钙分散片0.5 g,po,tid,观察组在对照组基础上再加服百令胶囊2.5 g,po,tid。疗程均为3个月。观察两组患者治疗前后血糖、血脂、糖化血红蛋白,以及血肌酐(Cr)、尿素氮(BUN)、内皮素(ET-1)、β2微球蛋白(β2-MG)、胱抑素(CYC)、24h尿蛋白定量(UAER)等指标变化情况,观察治疗期间药品不良反应发生情况。结果：治疗后,两组BUN、Cr、ET-1、UAER、β2-MG、CYC等指标均较治疗前显著下降( P<0.05),且观察组上述指标均明显低于对照组(P<0.05)。两组患者治疗前后血糖、血脂、糖化血红蛋白等指标无明显变化(P>0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论：百令胶囊联合羟苯磺酸钙分散片治疗糖尿病肾病Ⅳ期,能明显改善患者肾功能指标,优于单用羟苯磺酸钙分散片,对血糖、血脂无明显影响,且安全性好。
목적：：관찰백령효낭연합간분광산개분산편치료당뇨병신병Ⅳ기,대환자혈당、혈지,신공능등지표적영향。방법：216례당뇨병신병Ⅳ기환자수궤분위량조각108례。대조조재상규치료기출상가복간분광산개분산편0.5 g,po,tid,관찰조재대조조기출상재가복백령효낭2.5 g,po,tid。료정균위3개월。관찰량조환자치료전후혈당、혈지、당화혈홍단백,이급혈기항(Cr)、뇨소담(BUN)、내피소(ET-1)、β2미구단백(β2-MG)、광억소(CYC)、24h뇨단백정량(UAER)등지표변화정황,관찰치료기간약품불량반응발생정황。결과：치료후,량조BUN、Cr、ET-1、UAER、β2-MG、CYC등지표균교치료전현저하강( P<0.05),차관찰조상술지표균명현저우대조조(P<0.05)。량조환자치료전후혈당、혈지、당화혈홍단백등지표무명현변화(P>0.05)。량조약품불량반응발생솔비교,차이무통계학의의(P>0.05)。결론：백령효낭연합간분광산개분산편치료당뇨병신병Ⅳ기,능명현개선환자신공능지표,우우단용간분광산개분산편,대혈당、혈지무명현영향,차안전성호。
Objective:To explore the therapeutic effect on blood glucose, lipid, and renal function of Bailing capsules combined with calcium dobesilate dispersible tablets in the treatment of diabetic nephropathy. Methods: Totally 216 patients with diabetic ne-phropathy in phase Ⅳ were randomly divided into the control group (108 cases) and the treatment group (108 cases). The control group was given the conventional therapy, and the treatment group was treated with Bailing capsules combined with calcium dobesilate dispersible tablets additionally. The levels of serum creatine (Scr), urean ntrogen (BUN), endothelin (ET-1), β2-microglobulin (β2-MG) ,cystatin C ( CYC) and urinary albumin excretion rate ( UAER) were detected for all the patients before and after the treat-ment. The adverse drug reactions were observed as well. Results:After the treatment, all the indices in the two groups were all obvi-ously decreased (P<0. 05), and those in the treatment group were significantly lower than those in the control group (P<0. 05). There were no significant changes in blood glucose, blood lipid and glycosylated hemoglobin before and after the treatment in the two groups (P>0. 05). The adverse drug reactions showed no significant differences between the two groups (P>0. 05). Conclusion:The effect of Bailing capsules combined with calcium dobesilate dispersible tablets is better than that of calcium dobesilate dispersible tablets in the treatment of diabetic nephropathy in phase IV, which can improve the renal function indices with high safety and without notable influence on blood glucose and lipid.