中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
6期
973-974,975
,共3页
米索前列醇%给药途径%产后出血
米索前列醇%給藥途徑%產後齣血
미색전렬순%급약도경%산후출혈
Misoprostol%Route of administration%Postpartum hemorrhage
目的：：比较米索前列醇舌下及直肠给药两种给药途径预防产后出血的疗效。方法：72例自然分娩产妇随机分为两组,每组36例,舌下组在胎儿前肩娩出后立即给予米索前列醇600μg舌下含化；直肠组则给予米索前列醇600μg深部肛塞。比较两组产妇在产后2 h、24 h的出血量及用药前后的心率和血压变化,观察用药后的不良反应。结果：产后2h、24 h,舌下组阴道出血量和产后出血发生率均显著低于直肠组(P<0.05)。两组用药前后心率和血压的变化及不良反应发生率差异无统计学意义(P>0.05),但舌下组寒战发生率显著高于直肠组(P<0.05)。结论：米索前列醇舌下含化用于预防自然分娩产后出血,效果显著,安全便捷,值得在临床上推广。
目的：：比較米索前列醇舌下及直腸給藥兩種給藥途徑預防產後齣血的療效。方法：72例自然分娩產婦隨機分為兩組,每組36例,舌下組在胎兒前肩娩齣後立即給予米索前列醇600μg舌下含化；直腸組則給予米索前列醇600μg深部肛塞。比較兩組產婦在產後2 h、24 h的齣血量及用藥前後的心率和血壓變化,觀察用藥後的不良反應。結果：產後2h、24 h,舌下組陰道齣血量和產後齣血髮生率均顯著低于直腸組(P<0.05)。兩組用藥前後心率和血壓的變化及不良反應髮生率差異無統計學意義(P>0.05),但舌下組寒戰髮生率顯著高于直腸組(P<0.05)。結論：米索前列醇舌下含化用于預防自然分娩產後齣血,效果顯著,安全便捷,值得在臨床上推廣。
목적：：비교미색전렬순설하급직장급약량충급약도경예방산후출혈적료효。방법：72례자연분면산부수궤분위량조,매조36례,설하조재태인전견면출후립즉급여미색전렬순600μg설하함화；직장조칙급여미색전렬순600μg심부항새。비교량조산부재산후2 h、24 h적출혈량급용약전후적심솔화혈압변화,관찰용약후적불량반응。결과：산후2h、24 h,설하조음도출혈량화산후출혈발생솔균현저저우직장조(P<0.05)。량조용약전후심솔화혈압적변화급불량반응발생솔차이무통계학의의(P>0.05),단설하조한전발생솔현저고우직장조(P<0.05)。결론：미색전렬순설하함화용우예방자연분면산후출혈,효과현저,안전편첩,치득재림상상추엄。
Objective:To compare the effect of misoprostol respectively with sublingual administration and rectal administration in the treatment of postpartum hemorrhage. Methods:Totally 72 pregnant women were randomly divided into two groups with 36 cases in each. The sublingual group was given misoprostol 600 μg under the tongue immediately after the front shoulder of baby was delivered, while the rectal group was given misoprostol 600μg into rectum deeply. The amount of blood loss in 2 hours and 24 hours after the de-livery and the adverse reactions were compared between the two groups. Results: The postpartum hemorrhageon in 2 hours and 24 hours of the sublingual group was significantly less than that of the rectal group, and the incidence of postpartum hemorrhage in the sub-lingual group was significantly lower than that of the rectal group, and the difference was statistically significant (P<0. 05). After the treatment, the incidence of adverse reactions between the two groups had no significant difference (P>0. 05). However, the incidence of shiver in the sublingual group was significantly higher than that in the rectal group, and the difference was statistically significant ( P<0. 05). Conclusion:The preventive effect of misoprostol with sublingual administration on postpartum hemorrhage after natural vagi-nal delivery is better than that with rectal administration, which is safe and convenient, and worthy of promoted application in clinics.
