CAJ | 학술논문

目的：探讨血清人附睾蛋白4(HE4)、肿瘤特异性生长因子(TSGF)和肿瘤抗原(CA125)联合检测对卵巢癌的诊断价值。方法选取卵巢癌患者70例为研究对象，另选择60例卵巢良性肿瘤患者为对照组，检测并比较卵巢良性肿瘤、卵巢癌Ⅰ期及卵巢癌Ⅱ、Ⅲ期间HE4、CA125及TSGF水平的差异。观察HE4、CA125及TSGF与卵巢癌侵袭性关系(周围浸润、淋巴结转移及复发)，并分析单项指标及联合应用对卵巢癌诊断的敏感性、特异性、阳性预测值、阴性预测值及诊断效率。结果卵巢良性肿瘤、卵巢癌Ⅰ期及卵巢癌Ⅱ、Ⅲ期三组比较， HE4、CA125及TSGF呈递增趋势，且三组间比较差异具有统计学意义(P<0.05)。与不伴有周围浸润、淋巴结转移及复发的卵巢癌比较，存在周围浸润、淋巴结转移及复发的卵巢癌患者HE4、CA125及TSGF水平均显著升高，差异具有统计学意义(P<0.05)。单项比较，CA125诊断敏感性最高，HE4诊断特异性及诊断效率最高。与单项指标比较，联合检测的敏感性、阳性预测值、阴性预测值及诊断效率更高，且差异具有统计学意义(P<0.05)。结论血清HE4、TSGF和CA125联合检测对卵巢癌诊断效率高，值得临床推广应用。
목적：탐토혈청인부고단백4(HE4)、종류특이성생장인자(TSGF)화종류항원(CA125)연합검측대란소암적진단개치。방법선취란소암환자70례위연구대상，령선택60례란소량성종류환자위대조조，검측병비교란소량성종류、란소암Ⅰ기급란소암Ⅱ、Ⅲ기간HE4、CA125급TSGF수평적차이。관찰HE4、CA125급TSGF여란소암침습성관계(주위침윤、림파결전이급복발)，병분석단항지표급연합응용대란소암진단적민감성、특이성、양성예측치、음성예측치급진단효솔。결과란소량성종류、란소암Ⅰ기급란소암Ⅱ、Ⅲ기삼조비교， HE4、CA125급TSGF정체증추세，차삼조간비교차이구유통계학의의(P<0.05)。여불반유주위침윤、림파결전이급복발적란소암비교，존재주위침윤、림파결전이급복발적란소암환자HE4、CA125급TSGF수평균현저승고，차이구유통계학의의(P<0.05)。단항비교，CA125진단민감성최고，HE4진단특이성급진단효솔최고。여단항지표비교，연합검측적민감성、양성예측치、음성예측치급진단효솔경고，차차이구유통계학의의(P<0.05)。결론혈청HE4、TSGF화CA125연합검측대란소암진단효솔고，치득림상추엄응용。
Objective To explore the diagnostic efficiency of combined detection of serum human epididymis protein 4 (HE4), tumor specific growth factor (TSGF) and cancer antigen 125 (CA125) in ovarian cancer. Methods Sev-enty patients with ovarian cancer were selected as the research objects, and sixty patients with benign ovarian tumor were enrolled as the control group. The difference in HE4, CA125 and TSGF levels were analyzed among benign ovarian tu-mor, phaseⅠovarian cancer, phaseⅡ~Ⅲovarian cancer. Relations between HE4, CA125, TSGF and ovarian cancer invasiveness (surrounding invasion, lymph node metastasis and relapse) were observed. The effects of single detection (using one index) and combined detection (combined application of the indexes for detection) on the sensitivity, speci-ficity, positive predictive value, negative predictive value and diagnostic efficiency in the diagnosis of ovarian cancer were analyzed. Results HE4, CA125 and TSGF increased successively in benign ovarian tumor, phaseⅠovarian can-cer, phase Ⅱ~Ⅲ ovarian cancer, and the differences among the three groups were statistically significant (P<0.05). HE4, CA125 and TSGF levels of patients with ovarian cancer invasion, lymph node metastasis and recurrence were significantly elevated (P<0.05). In comparison of single index, CA125 had the highest sensitivity of diagnosis, and HE4 had the highest specificity and diagnostic efficiency. Compared with single detection, combined detection results in significantly higher sensitivity, positive predictive value, negative predictive value, and diagnostic efficiency (P<0.05). Conclusion Combined detection of serum HE4, TSGF and CA125 have high efficiency in the diagnosis of ovarian cancer. It is worthy of clinical application.