海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
11期
1631-1633
,共3页
银屑病关节炎%外周血%转化生长因子β1%临床检测%意义
銀屑病關節炎%外週血%轉化生長因子β1%臨床檢測%意義
은설병관절염%외주혈%전화생장인자β1%림상검측%의의
Psoriatic arthritis%Peripheral blood%Transforming growth factorβ1%Clinical examination%Significance
目的：研究银屑病关节炎(PsA)患者检测外周血转化生长因子β1(TGF-β1)的临床意义。方法将2009年3月至2013年3月在我院接受治疗的64例PsA患者纳入观察组，另选同期在我院接受健康体检的志愿者64例作为对照组。在患者治疗前和治疗中，病情基本痊愈之后以及部分患者复发时(健康对照组则在常规体检时进行)对比两组受试者的TGF-β1及表皮生长因子(EGF)水平，分析不同银屑病面积和严重程度指数(PASI)评分的PsA患者外周血TGF-β1及EGF水平，以及PsA患者不同治疗时期的外周血TGF-β1水平。结果观察组患者的TGF-β1水平明显低于对照组，EGF水平明显高于对照组，差异均有统计学意义(P<0.05)。根据Spearman法分析相关性可知，随着PASI评分不断增加，PsA患者TGF-β1水平随之降低，二者呈现为负相关(r=-0.873，P=0.000)，但患者PASI评分增加的同时，EGF水平无明显变化，二者无明显相关性(r=0.218，P=0.964)。PsA患者治疗中与治疗后的TGF-β1水平均明显高于治疗前的水平，PASI评分水平均明显低于治疗前的水平，差异均有统计学意义(P<0.05)。PsA复发患者的TGF-β1及PASI评分水平与治疗前比较，差异均无统计学意义(P>0.05)。结论检测PsA患者外周血TGF-β1可较好地反映其疾病进展情况，可用于评估其治疗疗效。
目的：研究銀屑病關節炎(PsA)患者檢測外週血轉化生長因子β1(TGF-β1)的臨床意義。方法將2009年3月至2013年3月在我院接受治療的64例PsA患者納入觀察組，另選同期在我院接受健康體檢的誌願者64例作為對照組。在患者治療前和治療中，病情基本痊愈之後以及部分患者複髮時(健康對照組則在常規體檢時進行)對比兩組受試者的TGF-β1及錶皮生長因子(EGF)水平，分析不同銀屑病麵積和嚴重程度指數(PASI)評分的PsA患者外週血TGF-β1及EGF水平，以及PsA患者不同治療時期的外週血TGF-β1水平。結果觀察組患者的TGF-β1水平明顯低于對照組，EGF水平明顯高于對照組，差異均有統計學意義(P<0.05)。根據Spearman法分析相關性可知，隨著PASI評分不斷增加，PsA患者TGF-β1水平隨之降低，二者呈現為負相關(r=-0.873，P=0.000)，但患者PASI評分增加的同時，EGF水平無明顯變化，二者無明顯相關性(r=0.218，P=0.964)。PsA患者治療中與治療後的TGF-β1水平均明顯高于治療前的水平，PASI評分水平均明顯低于治療前的水平，差異均有統計學意義(P<0.05)。PsA複髮患者的TGF-β1及PASI評分水平與治療前比較，差異均無統計學意義(P>0.05)。結論檢測PsA患者外週血TGF-β1可較好地反映其疾病進展情況，可用于評估其治療療效。
목적：연구은설병관절염(PsA)환자검측외주혈전화생장인자β1(TGF-β1)적림상의의。방법장2009년3월지2013년3월재아원접수치료적64례PsA환자납입관찰조，령선동기재아원접수건강체검적지원자64례작위대조조。재환자치료전화치료중，병정기본전유지후이급부분환자복발시(건강대조조칙재상규체검시진행)대비량조수시자적TGF-β1급표피생장인자(EGF)수평，분석불동은설병면적화엄중정도지수(PASI)평분적PsA환자외주혈TGF-β1급EGF수평，이급PsA환자불동치료시기적외주혈TGF-β1수평。결과관찰조환자적TGF-β1수평명현저우대조조，EGF수평명현고우대조조，차이균유통계학의의(P<0.05)。근거Spearman법분석상관성가지，수착PASI평분불단증가，PsA환자TGF-β1수평수지강저，이자정현위부상관(r=-0.873，P=0.000)，단환자PASI평분증가적동시，EGF수평무명현변화，이자무명현상관성(r=0.218，P=0.964)。PsA환자치료중여치료후적TGF-β1수평균명현고우치료전적수평，PASI평분수평균명현저우치료전적수평，차이균유통계학의의(P<0.05)。PsA복발환자적TGF-β1급PASI평분수평여치료전비교，차이균무통계학의의(P>0.05)。결론검측PsA환자외주혈TGF-β1가교호지반영기질병진전정황，가용우평고기치료료효。
Objective To study the clinical significance of detecting TGF-β1 of patients with psoriatic arthri-tis (PsA). Methods Sixty-four patients with PsA who were treated in our hospital between March 2009 and March 2013 were selected as the observation group. Another 64 volunteers who were received physical examination in our hospital at the same time were selected as control group. TGF-β1 and the level of epidermal growth factor (EGF) of two group before treatment, in treatment, after basic recovery and recurrence of some patients (healthy control group in regular examination) were compared to analyze TGF in peripheral blood, EGF levels of PsA patients with different psoriasis areas and psoriasis severity index (PASI) score, and TGF in peripheral blood in different treatment period. Results TGF-β1 lev-el in observation group was significantly lower than that in control group, and EGF was significantly higher than that in control group. The differences were statistically significant (P<0.05). Spearman correlation analysis showed that TGF-β1 in PsA patients was decreased with the increasing of PASI score, with negative correlation (r=-0.873, P=0.000). There was no significant change in EGF levels when patients’PASI score was increasing, which had no signif-icant relationship between them (r=0.218,P=0.964). TGF-β1 of PsA patients in treatment and after treatment were both significantly higher than that before treatment, and PASI score were both lower than that before treatment. The differences were statistically significant (P<0.05). The difference of TGF-β1 and PASI scores of PsA recurrent patients was not statistically significant compared with that before treatment (P>0.05). Conclusion Detection of TGF-β1 in peripheral blood of PsA patients can better reflect progression of disease, which can be used to evaluate the curative ef-fect of treatment.
