CAJ | 학술논문

【目的】探讨不同干预措施对青春期肥胖型多囊卵巢综合征（PCOS ）患者性激素及其临床表现的影响。【方法】收集13～20岁青春期肥胖型PCOS患者127例，根据干预措施不同分为3组：A组（44例），生活方式调整＋炔雌醇环丙孕酮（达英‐35）＋盐酸二甲双胍治疗；B组（42例），仅用生活方式调整；C组（41例），达英‐35＋盐酸二甲双胍治疗，均干预3个月，比较各组干预后性激素水平和临床指标。【结果】三组治疗后体质量指数（BMI）均有显著性下降（ P ＜0．05），且A组BMI显著低于B组、C组（ P ＜0．05），但B组与C组比较差异无统计学意义（ P ＞0．05）。A组与C组治疗后的黄体生成素／卵泡刺激素（LH／FSH）、睾酮（T）均有显著下降（ P ＜0．05），B组治疗后LH／FSH、T 虽亦呈下降趋势，但与治疗前比较无显著性差异（ P ＞0．05）。三组治疗后月经异常改善明显，痤疮、多毛等改善不明显。【结论】生活方式调整联合达英‐35和盐酸二甲双胍通过降低PCOS患者BM I、L H／FS H及T水平，有效恢复月经，且其作用优于达英‐35和盐酸二甲双胍，但对多毛、痤疮等症状改善不明显。
【목적】탐토불동간예조시대청춘기비반형다낭란소종합정（PCOS ）환자성격소급기림상표현적영향。【방법】수집13～20세청춘기비반형PCOS환자127례，근거간예조시불동분위3조：A조（44례），생활방식조정＋결자순배병잉동（체영‐35）＋염산이갑쌍고치료；B조（42례），부용생활방식조정；C조（41례），체영‐35＋염산이갑쌍고치료，균간예3개월，비교각조간예후성격소수평화림상지표。【결과】삼조치료후체질량지수（BMI）균유현저성하강（ P ＜0．05），차A조BMI현저저우B조、C조（ P ＜0．05），단B조여C조비교차이무통계학의의（ P ＞0．05）。A조여C조치료후적황체생성소／란포자격소（LH／FSH）、고동（T）균유현저하강（ P ＜0．05），B조치료후LH／FSH、T 수역정하강추세，단여치료전비교무현저성차이（ P ＞0．05）。삼조치료후월경이상개선명현，좌창、다모등개선불명현。【결론】생활방식조정연합체영‐35화염산이갑쌍고통과강저PCOS환자BM I、L H／FS H급T수평，유효회복월경，차기작용우우체영‐35화염산이갑쌍고，단대다모、좌창등증상개선불명현。
[Objective] To explore the hormonal and symptomatic changes by different interventions for obese adolescents with polycystic ovary syndrome (PCOS) .[Methods]A total of 127 adolescents aged 13~20 years were recruited and divided randomly into three groups .That is group A ( n=44):lifestyle modification plus ethinyl estradiol cyproterone acetate (Daine‐35) plus metformin ,group B ( n=42):lifestyle modification alone and group C ( n=41):Daine‐35 plus metformin .[Results]All regimens were effective in lowering body mass index (BMI) ( P<0 .05) .And group A was more dramatic than groups B and C ( P <0 .05) .But no significant differences existed between lifestyle modification and medication ( P>0 .05) .Lifestyle modification plus medication and medication alone were both effective in lowering the ratio of luteinizing hormone (LH) to follicle stimulating hormone (FSH) and reducing the level of androgen (T) .And there were significant differ‐ences ( P < 0 .05) .Lifestyle modification alone was ineffective in lowering LH :FSH ratio and androgen . There were no significant differences ( P >0 .05) .But there was a trend of lowing LH :FSH ratio .All regi‐mens were effective in improving menstrual irregularity ,but none of them could improve acne and hirsutism ef‐fectively .[Conclusion] Lifestyle modification may lower BMI effectively ,but not T level .Lifestyle modifica‐tion plus medication medicine treatment are more effective than medication alone in lowering BMI and LH :FSH ratio and promoting regular menstruation .