中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
5期
443-446
,共4页
牛素英%杨林霖%邸亚丽%郭新字
牛素英%楊林霖%邸亞麗%郭新字
우소영%양림림%저아려%곽신자
低频重复经颅磁刺激%酒依赖%焦虑%抑郁%睡眠
低頻重複經顱磁刺激%酒依賴%焦慮%抑鬱%睡眠
저빈중복경로자자격%주의뢰%초필%억욱%수면
Low-frequency repetitive transcranial magnetic stimulation%Alcohol dependence%Anxiety%Depression%Sleep
目的 探讨低频重复经颅磁刺激(rTMS)对酒依赖戒断后所致的抑郁、焦虑和睡眠问题的改善作用.方法 将80例酒依赖住院患者采用随机数字表法分为实验组(40例)和对照组(40例).两组患者均接受常规治疗和护理,实验组加用低频重复经颅磁刺激治疗,刺激部位为双侧背外侧前额叶区(DLPFC)2个脑区,每侧各15 min,频率为1 Hz,刺激强度为患者运动阈值(MT)的80％,每周rTMS治疗5次,共治疗8周,伪rTMS组应用伪刺激线圈.于入组时,治疗后2周、4周、8周末均进行汉密尔顿焦虑量表(HAMA)、抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)评定.结果 接受rTMS治疗后,实验组治疗后第2周、4周、8周末HAMA评分分别为[(19.5±6.4)分、(13.8±5.3)分、(7.3±5.4)分],与治疗前同期评分差异有统计学意义(t2=11.29,P＜0.01;t4=15.26,P＜0.01;t 8=9.40,P＜0.01);与对照组比较,实验组在治疗后第2周,4周,第8周末HAMA评分差异有统计学意义(P＜0.01);在治疗后第2周、4周、8周末HAMD评分为[(17.5±6.6)分、(11.2±4.9)分、(6.1±5.2)分],与治疗前同期评分差异有统计学意义(t2=15.54,P＜0.01;t4=16.68,P＜0.01;t 8=18.77,P＜0.01);与对照组比较,实验组在治疗后第2周、4周、第8周末HAMD评分差异有统计学意义(P＜0.01).实验组治疗后第2周、4周、第8周末PSQI评分均显著低于对照组(t 2 =26.39,P＜0.01;t4=15.21,P＜0.01;t8=46.35,P＜0.01).结论 低频重复经颅磁刺激对酒依赖患者焦虑抑郁情绪、睡眠状况等有明显的改善作用.
目的 探討低頻重複經顱磁刺激(rTMS)對酒依賴戒斷後所緻的抑鬱、焦慮和睡眠問題的改善作用.方法 將80例酒依賴住院患者採用隨機數字錶法分為實驗組(40例)和對照組(40例).兩組患者均接受常規治療和護理,實驗組加用低頻重複經顱磁刺激治療,刺激部位為雙側揹外側前額葉區(DLPFC)2箇腦區,每側各15 min,頻率為1 Hz,刺激彊度為患者運動閾值(MT)的80％,每週rTMS治療5次,共治療8週,偽rTMS組應用偽刺激線圈.于入組時,治療後2週、4週、8週末均進行漢密爾頓焦慮量錶(HAMA)、抑鬱量錶(HAMD)、匹玆堡睡眠質量指數(PSQI)評定.結果 接受rTMS治療後,實驗組治療後第2週、4週、8週末HAMA評分分彆為[(19.5±6.4)分、(13.8±5.3)分、(7.3±5.4)分],與治療前同期評分差異有統計學意義(t2=11.29,P＜0.01;t4=15.26,P＜0.01;t 8=9.40,P＜0.01);與對照組比較,實驗組在治療後第2週,4週,第8週末HAMA評分差異有統計學意義(P＜0.01);在治療後第2週、4週、8週末HAMD評分為[(17.5±6.6)分、(11.2±4.9)分、(6.1±5.2)分],與治療前同期評分差異有統計學意義(t2=15.54,P＜0.01;t4=16.68,P＜0.01;t 8=18.77,P＜0.01);與對照組比較,實驗組在治療後第2週、4週、第8週末HAMD評分差異有統計學意義(P＜0.01).實驗組治療後第2週、4週、第8週末PSQI評分均顯著低于對照組(t 2 =26.39,P＜0.01;t4=15.21,P＜0.01;t8=46.35,P＜0.01).結論 低頻重複經顱磁刺激對酒依賴患者焦慮抑鬱情緒、睡眠狀況等有明顯的改善作用.
목적 탐토저빈중복경로자자격(rTMS)대주의뢰계단후소치적억욱、초필화수면문제적개선작용.방법 장80례주의뢰주원환자채용수궤수자표법분위실험조(40례)화대조조(40례).량조환자균접수상규치료화호리,실험조가용저빈중복경로자자격치료,자격부위위쌍측배외측전액협구(DLPFC)2개뇌구,매측각15 min,빈솔위1 Hz,자격강도위환자운동역치(MT)적80％,매주rTMS치료5차,공치료8주,위rTMS조응용위자격선권.우입조시,치료후2주、4주、8주말균진행한밀이돈초필량표(HAMA)、억욱량표(HAMD)、필자보수면질량지수(PSQI)평정.결과 접수rTMS치료후,실험조치료후제2주、4주、8주말HAMA평분분별위[(19.5±6.4)분、(13.8±5.3)분、(7.3±5.4)분],여치료전동기평분차이유통계학의의(t2=11.29,P＜0.01;t4=15.26,P＜0.01;t 8=9.40,P＜0.01);여대조조비교,실험조재치료후제2주,4주,제8주말HAMA평분차이유통계학의의(P＜0.01);재치료후제2주、4주、8주말HAMD평분위[(17.5±6.6)분、(11.2±4.9)분、(6.1±5.2)분],여치료전동기평분차이유통계학의의(t2=15.54,P＜0.01;t4=16.68,P＜0.01;t 8=18.77,P＜0.01);여대조조비교,실험조재치료후제2주、4주、제8주말HAMD평분차이유통계학의의(P＜0.01).실험조치료후제2주、4주、제8주말PSQI평분균현저저우대조조(t 2 =26.39,P＜0.01;t4=15.21,P＜0.01;t8=46.35,P＜0.01).결론 저빈중복경로자자격대주의뢰환자초필억욱정서、수면상황등유명현적개선작용.
Objective To investigate the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) treatment of patients with alcohol dependence,anxiety and depression,and sleep problems.Methods 80 patients with alcohol-dependent patients were randomly divided into experimental group (40 cases) and control group (40 cases).All patients received routine treatment and care,the experimental group received additional rTMS to stimulate parts of the bilateral dorsolateral prefrontal region (DLPFC) 2 brain regions,each side 15 minutes at frequency of 1Hz,patient motion stimulus,intensity threshold (MT) of 80％,five times a week rTMS treatment,a total of 8 weeks,the control group received stimulation coil.Subjects were interviewed,as the time for the baseline,2 weeks,4 weeks and 8 weeks,assessment tools for the hamilton anxiety scale (HAMA),Hamilton depression rating scale (HAMD),Pittsburgh sleep quality index (PSQI).Results Compared with the pre-treatment,HAMA scores (19.5 ± 6.4,13.8± 5.3,7.3± 5.4 respectively) were significantly lower in 2,4,8 weeks after treatment (t 2 =11.29,P＜0.01;t 4=15.26,P＜0.01;t s =9.40,P＜0.01).Compared with the control group,HAMA scores were significantly lower in the experimental group after treatment (P＜0.01).Compared with the pretreatment group HAMD scores(17.5±6.6,11.2±4.9,6.1±5.2 respectively)were significantly lower in 2,4,8 weeks after treatment (t 2 =15.54,P＜0.01;t 4 =16.68,P＜0.01;t s =18.77,P＜0.01).Compared with the control group,HAMD scores were significantly lower in the experimental group after treatment (P＜0.01).Compared with the control group,PSQI scores were significantly lower in the experimental group in 2,4,8 weeks after treatment (t 2 =26.39,P＜0.01;t4=15.21,P＜0.01;ts=46.35,P＜0.01).Condusion Low-frequency rTMS treatment for alcohol dependence withdrawal symptoms can improve symptoms,such as anxiety and depression,sleep status.
