中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
5期
455-457
,共3页
陈景旭%陈红梅%李居艳%李然%张喜梅%王绍礼%谭云龙
陳景旭%陳紅梅%李居豔%李然%張喜梅%王紹禮%譚雲龍
진경욱%진홍매%리거염%리연%장희매%왕소례%담운룡
双相障碍%同型半胱氨酸%躁狂发作
雙相障礙%同型半胱氨痠%躁狂髮作
쌍상장애%동형반광안산%조광발작
Bipolar disorder%Homocysteine%Manic episodes
目的 探讨双相Ⅰ型障碍躁狂发作患者血清同型半胱氨酸(Hcy)水平及其影响因素.方法 采用病例对照研究方法.选取符合美国精神障碍统计与诊断手册第4版(DSM-Ⅳ)诊断标准的住院双相Ⅰ型障碍躁狂发作患者(患者组)73例和健康对照者(对照组)39例.采用用循环酶法测定检测血清Hcy水平,用杨氏躁狂量表(YMRS)评定患者的躁狂症状.结果 血清Hcy水平在患者组[(16.89± 14.67)μmol/L]和对照组[(10.61±6.46) μmol/L]之间差异具有统计学意义(P<0.01),且男性患者血清Hcy水平[(20.42±16.52) μmol/L]显著高于女性患者[(10.87±8.02) μmol/L] (P<0.01).患者组高同型半胱氨酸血症发生率(35.6%)显著高于对照组(13.5%)(P<0.05).相关分析显示体质量指数(BMI)与血清Hcy水平呈正相关(r=0.317,P<0.05).逐步多元回归分析显示性别、BMI对血清Hcy水平有明显影响(均P<0.05).结论 双相Ⅰ型障碍躁狂发作患者血清Hcy水平升高,并与性别、BMI有关.
目的 探討雙相Ⅰ型障礙躁狂髮作患者血清同型半胱氨痠(Hcy)水平及其影響因素.方法 採用病例對照研究方法.選取符閤美國精神障礙統計與診斷手冊第4版(DSM-Ⅳ)診斷標準的住院雙相Ⅰ型障礙躁狂髮作患者(患者組)73例和健康對照者(對照組)39例.採用用循環酶法測定檢測血清Hcy水平,用楊氏躁狂量錶(YMRS)評定患者的躁狂癥狀.結果 血清Hcy水平在患者組[(16.89± 14.67)μmol/L]和對照組[(10.61±6.46) μmol/L]之間差異具有統計學意義(P<0.01),且男性患者血清Hcy水平[(20.42±16.52) μmol/L]顯著高于女性患者[(10.87±8.02) μmol/L] (P<0.01).患者組高同型半胱氨痠血癥髮生率(35.6%)顯著高于對照組(13.5%)(P<0.05).相關分析顯示體質量指數(BMI)與血清Hcy水平呈正相關(r=0.317,P<0.05).逐步多元迴歸分析顯示性彆、BMI對血清Hcy水平有明顯影響(均P<0.05).結論 雙相Ⅰ型障礙躁狂髮作患者血清Hcy水平升高,併與性彆、BMI有關.
목적 탐토쌍상Ⅰ형장애조광발작환자혈청동형반광안산(Hcy)수평급기영향인소.방법 채용병례대조연구방법.선취부합미국정신장애통계여진단수책제4판(DSM-Ⅳ)진단표준적주원쌍상Ⅰ형장애조광발작환자(환자조)73례화건강대조자(대조조)39례.채용용순배매법측정검측혈청Hcy수평,용양씨조광량표(YMRS)평정환자적조광증상.결과 혈청Hcy수평재환자조[(16.89± 14.67)μmol/L]화대조조[(10.61±6.46) μmol/L]지간차이구유통계학의의(P<0.01),차남성환자혈청Hcy수평[(20.42±16.52) μmol/L]현저고우녀성환자[(10.87±8.02) μmol/L] (P<0.01).환자조고동형반광안산혈증발생솔(35.6%)현저고우대조조(13.5%)(P<0.05).상관분석현시체질량지수(BMI)여혈청Hcy수평정정상관(r=0.317,P<0.05).축보다원회귀분석현시성별、BMI대혈청Hcy수평유명현영향(균P<0.05).결론 쌍상Ⅰ형장애조광발작환자혈청Hcy수평승고,병여성별、BMI유관.
Objective To explore the association between serum levels of homocysteine (Hcy) and relation factors in the patients with manic episodes of bipolar Ⅰ disorder(BD).Methods The case-control study was used for this study.A total of 73 inpatients with manic episodes of BD(patient group) and 39 healthy individuals (control group) were enrolled.Diagnosis was made according to the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition(DSM-Ⅳ) criteria.Serum levels of Hcy was measured by enzymatic cycling assay.Young Mania Rating Scale(YMRS) were used to assess the severity of clinical symptoms of patients.Results There was a statistical difference in serum Hcy levels between patient group ((16.89± 14.67)μmol/L) and control group ((10.61±6.46) μmol/L) (P<0.01),and serum Hcy levels was higher in men((20.42± 16.52) μmol/L) than that in women((10.87±8.02) μmol/L) in patients group(P<0.05).The prevalence rate of high Hcy was 35.6% in the patient group and 13.5% in the control group(P<0.05).Correlation analysis showed body mass index(BMI) had positive correlation with serum levels of Hcy (r=0.317,P<0.05).Stepwise multiple regression analysis showed male,BMI were associated with serum levels of Hcy among the patients (all P< 0.05).Conclusion Serum Hcy levels in the patients with manic episodes of bipolar Ⅰ disorder increase,and it is associated with gender and BMI.