CAJ | 학술논문

目的：研究神经节苷脂钠联合依达拉奉治疗急性脑出血的临床疗效。方法选择2010年9月至2014年9月广东三九脑科医院确诊为急性脑出血患者78例，依据随机数字表法分为两组，研究组（40例）在常规治疗基础上加用100 mg神经节苷脂注射液加入0．9％氯化钠注射液250 mL 静脉滴注，每日1次及30 mg依达拉奉加入0．9％氯化钠注射液100 mL静脉滴注，每日2次联合治疗；对照组（38例）在常规治疗基础上加用依达拉奉。两组治疗时间均为14 d。患者均予以神经功能缺损及日常生活能力量表评分，并在治疗结束后进行相应的复查，对其结果进行对比分析。结果研究组总有效率高于对照组（97．5％比76．3％），差异有统计学意义（P＜0．05）。治疗后，两组患者神经功能缺损评分较治疗前显著下降，日常生活能力量表评分显著升高，且研究组改善情况优于对照组，差异均有统计学意义（ P＜0．01）。结论对于治疗急性脑出血来说，神经节苷脂与依达拉奉联合应用临床疗效改善情况更为显著，值得在临床推广应用。
목적：연구신경절감지납연합의체랍봉치료급성뇌출혈적림상료효。방법선택2010년9월지2014년9월엄동삼구뇌과의원학진위급성뇌출혈환자78례，의거수궤수자표법분위량조，연구조（40례）재상규치료기출상가용100 mg신경절감지주사액가입0．9％록화납주사액250 mL 정맥적주，매일1차급30 mg의체랍봉가입0．9％록화납주사액100 mL정맥적주，매일2차연합치료；대조조（38례）재상규치료기출상가용의체랍봉。량조치료시간균위14 d。환자균여이신경공능결손급일상생활능역량표평분，병재치료결속후진행상응적복사，대기결과진행대비분석。결과연구조총유효솔고우대조조（97．5％비76．3％），차이유통계학의의（P＜0．05）。치료후，량조환자신경공능결손평분교치료전현저하강，일상생활능역량표평분현저승고，차연구조개선정황우우대조조，차이균유통계학의의（ P＜0．01）。결론대우치료급성뇌출혈래설，신경절감지여의체랍봉연합응용림상료효개선정황경위현저，치득재림상추엄응용。
Objective To study the clinical efficacy of the combined application of ganglioside sodium and edaravone on acute cerebral hemorrhage.Methods 78 patients with acute cerebral hemorrhage admitted to the Three Nine Brain Hospital of Guangdong from September 2010 to September 2014 were randomly divided into two groups.Study group ( 40 cases ) used plus ganglioside ( 0.9% sodium chloride injection 250 mL and ganglioside injection 100 mg,1 time/day) combined with edaravone ( intravenous drip for 0.9%sodium chloride injection edaravone injection 100 mL and edaravone injection 30 mg,2 times/day) based on the conventional treatment.Control group (38 cases) used edaravone based on the conventional treatment. All patients were treated with nerve function defect and activities of daily living scale score ,and correspond-ing review at the end of treatment,the comparative study of the results.Results The total efficiency of study group was significantly higher than that of control group(97.5% vs 76.3%)(P<0.05).After treatment, the neural function defect score of two groups were decreased before treatment,and the ability of daily living scale were increased before treatment,and study group were superior to that of control group(P <0.01). Conclusion For the treatment of acute cerebral hemorrhage,edaravone and ganglioside and application of clinical treatment of the improvement is more significant,it is worth to popularize in the clinical application .