CAJ | 학술논문

目的：探讨SP70抗原检测在癌性胸腔积液鉴别诊断中的应用价值。方法选取2013年1月至2014年1月达州陆军医院收治的200例胸腔积液患者作为研究对象、其中100例癌性胸腔积液，100例非癌性胸腔积液。患者的胸腔积液均检测SP70抗原、癌胚抗原（ CEA）、神经元特异性烯醇化酶（NSE）及细胞角质蛋白19片段（Cyfra21－1），并以病理检测结果为金标准，评价其在癌性胸腔积液鉴别诊断中的诊断效能。结果 SP70在诊断癌性胸腔积液时的灵敏度、特异度、准确度、阳性预测值、阴性预测值分别为70．0％、88．0％、79．0％、85．4％、74．6％。鳞癌、腺癌SP70抗原阳性检出率分别为76．5％和83．0％，均高于小细胞癌的26．3％，差异有统计学意义（χ2＝12．628，19．549，均P＜0．05）。结论与传统的肿瘤标志物相比，SP70抗原在癌性胸腔积液鉴别诊断中具有更高的诊断效能，检测方法简单、无创，有较高的临床应用价值。
목적：탐토SP70항원검측재암성흉강적액감별진단중적응용개치。방법선취2013년1월지2014년1월체주륙군의원수치적200례흉강적액환자작위연구대상、기중100례암성흉강적액，100례비암성흉강적액。환자적흉강적액균검측SP70항원、암배항원（ CEA）、신경원특이성희순화매（NSE）급세포각질단백19편단（Cyfra21－1），병이병리검측결과위금표준，평개기재암성흉강적액감별진단중적진단효능。결과 SP70재진단암성흉강적액시적령민도、특이도、준학도、양성예측치、음성예측치분별위70．0％、88．0％、79．0％、85．4％、74．6％。린암、선암SP70항원양성검출솔분별위76．5％화83．0％，균고우소세포암적26．3％，차이유통계학의의（χ2＝12．628，19．549，균P＜0．05）。결론여전통적종류표지물상비，SP70항원재암성흉강적액감별진단중구유경고적진단효능，검측방법간단、무창，유교고적림상응용개치。
Objective To investigate the clinical application value of SP70 antigen in differential diag-nosis of malignant pleural effusion.Methods A total of 200 patients with pleural effusion admitted in Dazhou Army Hospital from Jan.2013 to Jan.2014 were selected as research objects,containing 100 cases of malignant pleural effusion and 100 cases of non-malignant pleural effusion.Levels of SP70 antigen and tumor markers carcino-embryonic antigen(CEA),neuron-specific enolase(NSE),cytokeratin19 fragment(Cyfra21-1) in pleural effusion were detected in all the patients.Taking pathologic detection results as the golden stand-ard,the value of SP70 was assessed in the diagnosis of malignant pleural effusion.Results The sensitivity, specificity,accuracy,positive predictive value,and negative predictive value of SP70 antigen in the diagnosis of malignant pleural effusion was 70.0%,88.0%,79.0%,85.4%,74.6%.Positive rates of squamous cell carcinoma and adenocarcinoma detected by SP70 antigen were 76.5% and 83.0%,significantly higher than that of small cell carcinoma(26.3%),the difference was statistically significant(χ2 =12.628,19.549,P<0.05).Conclusion Compared with conventional tumor markers,SP70 antigen has higher sensitivity and specificity in the diagnosis of malignant pleural effusion and is easily operated and noninvasive ,therefore,it is worthy of clinical application.