CAJ | 학술논문

目的观察老年脑梗死患者血浆同型半胱氨酸（Hcy）和胱抑素 C（Cys-C）的水平与神经功能缺损程度的相关性及临床意义。方法检测82例老年脑梗死患者血浆 Hcy 和 Cys-C 水平，并与60例非脑血管病患者作为对照组进行比较。根据美国国立卫生研究院卒中量表（NIHSS）评分，将脑梗死组分为轻、中、重度3组，并将各组各项指标之间进行比较。结果脑梗死组血浆Hcy、Cys-C 水平明显高于对照组，且临床分组血浆 Hcy、Cys-C 水平两两比较差异有统计学意义（P＜0．05）；脑梗死患者血浆 Hcy、Cys-C 水平与 NIHSS 评分呈正相关（r ＝0．54，P ＜0．05；r ＝0．45，P＜0．05）。结论血浆 Hcy、Cys-C 水平与脑梗死的严重程度密切相关，提示血浆 Hcy、Cys-C 水平的动态监测对脑梗死的预测和疗效观察有临床意义。
목적관찰노년뇌경사환자혈장동형반광안산（Hcy）화광억소 C（Cys-C）적수평여신경공능결손정도적상관성급림상의의。방법검측82례노년뇌경사환자혈장 Hcy 화 Cys-C 수평，병여60례비뇌혈관병환자작위대조조진행비교。근거미국국립위생연구원졸중량표（NIHSS）평분，장뇌경사조분위경、중、중도3조，병장각조각항지표지간진행비교。결과뇌경사조혈장Hcy、Cys-C 수평명현고우대조조，차림상분조혈장 Hcy、Cys-C 수평량량비교차이유통계학의의（P＜0．05）；뇌경사환자혈장 Hcy、Cys-C 수평여 NIHSS 평분정정상관（r ＝0．54，P ＜0．05；r ＝0．45，P＜0．05）。결론혈장 Hcy、Cys-C 수평여뇌경사적엄중정도밀절상관，제시혈장 Hcy、Cys-C 수평적동태감측대뇌경사적예측화료효관찰유림상의의。
Objective To observe plasma levels of homocysteine(Hcy)and cystatin C(Cys-C) in elderly patients with cerebral infarction and to investigate their clinical value as well as associations with neurologic deficit.Methods We compared plasma Hcy and Cys-C concentrations in 82 cases of cerebral infarction with those in 60 controls.82 cases of cerebral infarction were divided into three groups according to their National Institutes of Health Stroke Scale(NIHSS)scores,among which groups Hcy and Cys-C were compared.Results Mean plasma levels of Hcy and Cys-C in stroke patients were significantly higher than those of controls(P <0.05)and had positive correlation with NIHSS scores(r =0.54,P <0.05;r =0.45,P <0.05).Moreover,Hcy and Cys-C concentrations were found significant differences among those three stroke groups(P <0.05).Conclusion Plasma levels of Hcy and Cys-C were related with the severity of cerebral infarction,therefore it is of great clinical value to measure their dynamic concentra-tions.