中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2015年
12期
1806-1808,1809
,共4页
唐普润%邓素娟%钟乐璇%胡湘
唐普潤%鄧素娟%鐘樂璇%鬍湘
당보윤%산소연%종악선%호상
传染性单核细胞增多症%淋巴细胞亚群
傳染性單覈細胞增多癥%淋巴細胞亞群
전염성단핵세포증다증%림파세포아군
Infectious mononucleosis%Lymphocyte subsets
目的:探讨儿童传染性单核细胞增多症(IM)异型淋巴细胞计数、淋巴细胞亚群的变化与临床表现的相互关系。方法采用回顾性的研究方法,收集确诊为 IM的住院患儿206例,分析异型淋巴细胞、淋巴细胞亚群变化和临床症状及三者相互关系。结果IM患儿 CD +3升高、CD +3 CD +4降低、CD +3 CD +8升高及NK 计数降低,健康对照组患儿分别为(64.23±6.26)%、(32.96±8.68)%、(20.25±7.45)%、(14.68±5.4)%,而 IM患儿分别为(84.13±14.64)%、(18.45±5.14)%、(54.46±16.82)%、(4.65±1.50)%,两组差异有统计学意义(P <0.001)。90.29%患儿异型淋巴细胞增高≥10%,异型淋巴细胞计数越高的患儿,淋巴细胞亚群异常越明显,异型淋巴细胞≥20%的患儿,CD +3 CD +8升高和 NK 细胞计数降低更为明显,分别为(58.78±16.67)%、(3.28±1.57)%,异型淋巴细胞<20%>10%与<10%组差异有统计学意义(P <0.001),分别为(54.53±15.12)%、(4.55±1.64)%及(50.25±14.23)%、(5.13±1.84)%。重症 IM较轻型IM患儿及对照组患儿相比,CD +3 CD +8升高和 NK 细胞计数降低更为明显,分别为(57.78±15.45)%、(3.18±1.61)%、(51.09±12.26)%、(4.68±1.82)%、(20.25±7.45)%、(14.68±5.46)%,差异有统计学意义(P <0.001)。结论IM存在免疫功能异常,异型淋巴细胞的数量、CD +3、CD +3 CD +4、CD +3 CD +8和 NK 计数可作为病情观察监测指标。
目的:探討兒童傳染性單覈細胞增多癥(IM)異型淋巴細胞計數、淋巴細胞亞群的變化與臨床錶現的相互關繫。方法採用迴顧性的研究方法,收集確診為 IM的住院患兒206例,分析異型淋巴細胞、淋巴細胞亞群變化和臨床癥狀及三者相互關繫。結果IM患兒 CD +3升高、CD +3 CD +4降低、CD +3 CD +8升高及NK 計數降低,健康對照組患兒分彆為(64.23±6.26)%、(32.96±8.68)%、(20.25±7.45)%、(14.68±5.4)%,而 IM患兒分彆為(84.13±14.64)%、(18.45±5.14)%、(54.46±16.82)%、(4.65±1.50)%,兩組差異有統計學意義(P <0.001)。90.29%患兒異型淋巴細胞增高≥10%,異型淋巴細胞計數越高的患兒,淋巴細胞亞群異常越明顯,異型淋巴細胞≥20%的患兒,CD +3 CD +8升高和 NK 細胞計數降低更為明顯,分彆為(58.78±16.67)%、(3.28±1.57)%,異型淋巴細胞<20%>10%與<10%組差異有統計學意義(P <0.001),分彆為(54.53±15.12)%、(4.55±1.64)%及(50.25±14.23)%、(5.13±1.84)%。重癥 IM較輕型IM患兒及對照組患兒相比,CD +3 CD +8升高和 NK 細胞計數降低更為明顯,分彆為(57.78±15.45)%、(3.18±1.61)%、(51.09±12.26)%、(4.68±1.82)%、(20.25±7.45)%、(14.68±5.46)%,差異有統計學意義(P <0.001)。結論IM存在免疫功能異常,異型淋巴細胞的數量、CD +3、CD +3 CD +4、CD +3 CD +8和 NK 計數可作為病情觀察鑑測指標。
목적:탐토인동전염성단핵세포증다증(IM)이형림파세포계수、림파세포아군적변화여림상표현적상호관계。방법채용회고성적연구방법,수집학진위 IM적주원환인206례,분석이형림파세포、림파세포아군변화화림상증상급삼자상호관계。결과IM환인 CD +3승고、CD +3 CD +4강저、CD +3 CD +8승고급NK 계수강저,건강대조조환인분별위(64.23±6.26)%、(32.96±8.68)%、(20.25±7.45)%、(14.68±5.4)%,이 IM환인분별위(84.13±14.64)%、(18.45±5.14)%、(54.46±16.82)%、(4.65±1.50)%,량조차이유통계학의의(P <0.001)。90.29%환인이형림파세포증고≥10%,이형림파세포계수월고적환인,림파세포아군이상월명현,이형림파세포≥20%적환인,CD +3 CD +8승고화 NK 세포계수강저경위명현,분별위(58.78±16.67)%、(3.28±1.57)%,이형림파세포<20%>10%여<10%조차이유통계학의의(P <0.001),분별위(54.53±15.12)%、(4.55±1.64)%급(50.25±14.23)%、(5.13±1.84)%。중증 IM교경형IM환인급대조조환인상비,CD +3 CD +8승고화 NK 세포계수강저경위명현,분별위(57.78±15.45)%、(3.18±1.61)%、(51.09±12.26)%、(4.68±1.82)%、(20.25±7.45)%、(14.68±5.46)%,차이유통계학의의(P <0.001)。결론IM존재면역공능이상,이형림파세포적수량、CD +3、CD +3 CD +4、CD +3 CD +8화 NK 계수가작위병정관찰감측지표。
Objective To investigate atypical lymphocyte and lymphocyte subsets in children with infectious mononucleosis(IM)and its relationship with the clinical symptoms by retrospective method.Methods Two hundred and six children were diagnosed as infectious mononucleosis.Atypical types,lymphocyte subsets,and clinical symp-toms and their relationship were evaluated and analyzed.Results In the IM children CD +3 increased,CD +3 CD +4 decreased,CD +3 CD +8 increased and NK cells decreased.The control group was (64.23 ±6.26 )%,(32.96 ± 8.68)%,(20.25 ±7.45)%,(14.68 ±5.4)%,the IMgroup was (84.13 ±14.64)%,(18.45 ±5.14)%,(54.46 ± 16.82)%,(4.65 ±1.50)%,the difference was statistically significant(P <0.001).92.9% patients had more 10%atypical lymphocytes.The children with more than 20% atypical lymphocytes had higher CD +3 CD +v8 and NK cells decreased,(58.78 ±16.67)%,(3.28 ±1.57)%.The difference with the atypical cells more than 10% less than 20% and the group less than 10% has statistically sighnificant which were (54.53 ±15.12)%,(4.55 ±1.64)%, (50.25 ±14.23)%,(5.13 ±1.84)% (P <0.001).The serious type of IM children had higher ratio of increased CD +3 CD +8 and decreased NK cells and had statistically significant compared with the light group,which were (57.78 ± 15.45)%,(3.18 ±1.61)%,(51.09 ±12.26)%,(4.68 ±1.82)%,(20.25 ±7.45)%,(14.68 ±5.46)%(P <0.001).Conclusion The infectious mononucleosis can cause abnormal immune functions.The ratio of atypical lym-phocytes,CD +3 ,CD +3 CD +4 ,CD +3 CD +8 and NK cells numbers can be viewed as a monitoring index of the disease.