CAJ | 학술논문

目的：观察调强放疗同步 TP方案化疗结合腔内后装放疗治疗中晚期宫颈癌的近期疗效。方法将58例中晚期宫颈癌患者按治疗方法不同分为观察组（同步放化疗组30例）和对照组（单纯放疗组28例），两组患者的放疗方法相同，均采用体外调强放疗加腔内后装放疗的方法，观察组采用 TP 方案同步放化疗，比较两组患者近期疗效、不良反应。结果对照组有效率为71．4％，观察组有效率为83．3％，两组有效率差异有统计学意义（χ2＝4．247，P ＜0．05）；两组不良反应主要为骨髓抑制、消化道反应、放射性膀胱炎、放射性直肠炎，但两组不良反应发生率差异无统计学意义（P ＞0．05）。结论同步放化疗治疗中晚期宫颈癌可提高患者近期疗效。
목적：관찰조강방료동보 TP방안화료결합강내후장방료치료중만기궁경암적근기료효。방법장58례중만기궁경암환자안치료방법불동분위관찰조（동보방화료조30례）화대조조（단순방료조28례），량조환자적방료방법상동，균채용체외조강방료가강내후장방료적방법，관찰조채용 TP 방안동보방화료，비교량조환자근기료효、불량반응。결과대조조유효솔위71．4％，관찰조유효솔위83．3％，량조유효솔차이유통계학의의（χ2＝4．247，P ＜0．05）；량조불량반응주요위골수억제、소화도반응、방사성방광염、방사성직장염，단량조불량반응발생솔차이무통계학의의（P ＞0．05）。결론동보방화료치료중만기궁경암가제고환자근기료효。
Objective To observe the clinical efficacy and adverse reactions of intensity modulated radio-therapy(IMRT)syn -chronization TP chemotherapy combined with afterloading radiotherapy for advanced cervical cancer.Methods 58 cases of advanced cervical cancer patients were randomly divided into the chemotherapy combi-nation with radiotherapy(observation group,30cases)and radiotherapy alone(control group,28cases),Both groups were treated with external IMRT combined with afterloading radiotherapy,patients of the observation group were accepted concurrent chemoradiotherapy for TP regimen,and the patents of the control group were only accepted radio-therapy,the short -term curative effect,adverse reactions of the two groups were compared.Results The effective rate of the control group was 71.4%,which of the observation group was 83.3%.the observation group short -term curative effect was better than that of control group,with a significant difference(χ2 =4.247,P <0.05),whereas the incidence rates of radiation cystitis,radiation proctitis,myelosuppresson and digestive tract reaction were not signifi-cantly different between two groups(P >0.05)no serious.Conclusion It can allow the patients with advanced cervi-cal cancer to benefit from the concurrent chemoradiotherapy.