CAJ | 학술논문

目的：探讨急性脑梗死患者超敏C反应蛋白（hs-CRP）及血脂水平检测的意义。方法分别检测300例急性脑梗死患者和300例健康体检成年人 hs-CRP 与血脂水平，并进行统计分析。结果研究组hs-CRP、总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白分别为（25．9±5．2）mmol／L、（7．5±2．3）mmol／L、（2．8±0．21）mmol／L、（0．8±0．1）mmol／L、（3．3±0．2）mmol／L；对照组 hs-CRP、总胆固醇、血三酰甘油、低密度脂蛋白、高密度脂蛋白分别为（6．3±1．2）mmol／L、（4．2±0．2）mmol／L、（1．5±0．2）mmol／L、（2．2±1．5）mmol／L、（2．5±0．5）mmol／L，两组差异均有统计学意义（t ＝5．9、5．1、4．8、4．6、和4．5，均 P ＜0．05）。Logistic 多因素回归分析显示总胆固醇、血三酰甘油、血低密度脂蛋白胆固醇、血高密度脂蛋白胆固醇、hs-CRP为急性脑梗死的独立危险因素（β＝0．53、0．68、0．69、1．20、0．69；S．E ＝0．23、0．16、0．28、0．24、0．25，OR ＝5．6、4．8、6．2、7．8、9．2；95％CI ＝0．58～38．50、0．69～36．80、0．57～35．70、0．68～44．20、0．21～48．20，P ＜0．01）。结论血脂代谢异常与 hs-CRP 为急性脑梗死患者的独立危险因素，脑梗死患者应该积极对血脂异常进行治疗。
목적：탐토급성뇌경사환자초민C반응단백（hs-CRP）급혈지수평검측적의의。방법분별검측300례급성뇌경사환자화300례건강체검성년인 hs-CRP 여혈지수평，병진행통계분석。결과연구조hs-CRP、총담고순、삼선감유、저밀도지단백、고밀도지단백분별위（25．9±5．2）mmol／L、（7．5±2．3）mmol／L、（2．8±0．21）mmol／L、（0．8±0．1）mmol／L、（3．3±0．2）mmol／L；대조조 hs-CRP、총담고순、혈삼선감유、저밀도지단백、고밀도지단백분별위（6．3±1．2）mmol／L、（4．2±0．2）mmol／L、（1．5±0．2）mmol／L、（2．2±1．5）mmol／L、（2．5±0．5）mmol／L，량조차이균유통계학의의（t ＝5．9、5．1、4．8、4．6、화4．5，균 P ＜0．05）。Logistic 다인소회귀분석현시총담고순、혈삼선감유、혈저밀도지단백담고순、혈고밀도지단백담고순、hs-CRP위급성뇌경사적독립위험인소（β＝0．53、0．68、0．69、1．20、0．69；S．E ＝0．23、0．16、0．28、0．24、0．25，OR ＝5．6、4．8、6．2、7．8、9．2；95％CI ＝0．58～38．50、0．69～36．80、0．57～35．70、0．68～44．20、0．21～48．20，P ＜0．01）。결론혈지대사이상여 hs-CRP 위급성뇌경사환자적독립위험인소，뇌경사환자응해적겁대혈지이상진행치료。
Objective To investigate the levels of hypersensitive C-reactive protein(hs-CRP)and serum lipid in patients with acute cerebral infarction.Methods A total of 300 patients with acute cerebral infarction and 300 healthy subjects (normal controls)were included in this study.The levels of hypersensitive C -reactive protein and serum lipid were measured and analyzed via statistics soft.Results The levels of hs-CRP,total cholesterol, triglyceride,low density lipoprotein and high density lipoprotein in the research group were (25.9 ±5.2)mmol/L, (7.5 ±2.3)mmol/L,(2.8 ±0.21)mmol/L,(0.8 ±0.1)mmol/L and (3.3 ±0.2)mmol/L respectively;The levels of hs-CRP,total cholesterol,triglyceride,low density lipoprotein and high density lipoprotein in the control group were (6.3 ±1.2)mmol/L,(4.2 ±0.2)mmol/L,(1.5 ±0.2)mmol/L,(2.2 ±1.5)mmol/L and(2.5 ±0.5)mmol/Lrespectively.There was a significant statistically difference between the two groups(t =5.9,5.1,4.8,4.6 and 4.5,all P <0.05).Multivariate Logistic regression analysis showed that total cholesterol,triglyceride,low density lipoprotein and high density lipoprotein hs-CRP were independent risk factors for the acute cerebral infarction (beta respectively 0.53,0.68,0.69,1.20,0.69;S.E were 0.23,0.16,0.28,0.24,0.25,OR values were 5.6,4.8,6.2,7.8,9.2;95%CI were 0.69 -36.8,0.57 -35.7,0.58 -38.5,0.68 -44.2,0.21 -48.2,all P <0.01).Conclusion The abnormal metabolism of serum lipid and C -reactive protein were independent risk factors in patients with acute cere-bral infarction,which should be positively treated about this.