CAJ | 학술논문

目的：探讨车前子醇提取物对不同糖尿病造模类型实验小鼠的降血糖效果。方法分别采用不同类型的糖尿病小鼠模型，即肾上腺素性高血糖小鼠模型、葡萄糖性高血糖小鼠模型以及四氧嘧啶性糖尿病小鼠模型进行实验。结果车前子醇提取物的高剂量组[（10．26±1．76）mmol／L]对肾上腺素性高血糖小鼠[（14．74±2．47）mmol／L]具有极明显的降血糖作用（t ＝2．558，P ＜0．01）；中剂量组[（11．74±2．35）mmol／L]对肾上腺素性高血糖小鼠具有明显的降血糖作用（t ＝1．524，P ＜0．05）；车前子醇提取物的高剂量组[（11．38±1．76）mmol／L]对葡萄糖性高血糖小鼠[（16．15±2．49）mmol／L]具有极明显的降血糖作用（t ＝2．710，P ＜0．01），中剂量组[（13．01±3．23）mmol／L]对葡萄糖性高血糖小鼠具有明显的降血糖作用（t ＝1．334，P ＜0．05）。结论车前子醇提取物在一定程度上具有明显的降低血糖作用。
목적：탐토차전자순제취물대불동당뇨병조모류형실험소서적강혈당효과。방법분별채용불동류형적당뇨병소서모형，즉신상선소성고혈당소서모형、포도당성고혈당소서모형이급사양밀정성당뇨병소서모형진행실험。결과차전자순제취물적고제량조[（10．26±1．76）mmol／L]대신상선소성고혈당소서[（14．74±2．47）mmol／L]구유겁명현적강혈당작용（t ＝2．558，P ＜0．01）；중제량조[（11．74±2．35）mmol／L]대신상선소성고혈당소서구유명현적강혈당작용（t ＝1．524，P ＜0．05）；차전자순제취물적고제량조[（11．38±1．76）mmol／L]대포도당성고혈당소서[（16．15±2．49）mmol／L]구유겁명현적강혈당작용（t ＝2．710，P ＜0．01），중제량조[（13．01±3．23）mmol／L]대포도당성고혈당소서구유명현적강혈당작용（t ＝1．334，P ＜0．05）。결론차전자순제취물재일정정도상구유명현적강저혈당작용。
Objective To investigate the hypoglycemic effects of the ethanol extracts of Plantago asiatica in different diabetes animal models.Methods The different diabetes animal models (adrenaline -induced hyperglyce-mic models,glucose -induced hyperglycemic models,alloxan -induced hyperglycemic models)have been applied. Results Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(10.26 ±1.76)mmol/L] possessed obviously hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =2.558,P <0.01)and the middle dose[(11.74 ±2.35)mmol/L]possessed hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =1.524,P <0.05 );Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(11.38 ±1.76)mmol/L]possessed obviously hypoglycemic effects on glucose -induced hyperglycemic mice[(16.15 ±2.49)mmol/L](t =2.710,P <0.01 )and the middle dose [(13.01 ±3.23)mmol/L]possessed hypoglycemic effects on glucose -induced hyperglycemic mice(t =1.334,P <0.05);In addition,the ethanol extracts of Plantago asiatica could significantly inhibit the rise of blood glucose level and had certain hypoglycemic effect on halloxan -induced diabetic mice.Conclusion The ethanol extracts of Planta-go asiatica have a significant role in lowering blood glucose at a certain extent.