中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
9期
70-72
,共3页
李晓艳%申孟平%宫红梅%张冰
李曉豔%申孟平%宮紅梅%張冰
리효염%신맹평%궁홍매%장빙
枸橼酸咖啡因%新生儿%呼吸暂停
枸櫞痠咖啡因%新生兒%呼吸暫停
구연산가배인%신생인%호흡잠정
Caffeine citrate%Neonatorum%Apnea
目的:探讨不同剂量枸橼酸咖啡因治疗新生儿呼吸暂停的临床疗效。方法选择2013年1月~2014年7月本院收治的呼吸暂停新生儿82例作为研究对象,随机分为两组,每组41例,两组均采用枸橼酸咖啡因治疗新生儿呼吸暂停,观察组首次剂量为20mg/kg,静脉滴注,维持量为10mg/kg 持续静脉滴注,对照组按照传统的剂量首次剂量为20mg/kg,静脉滴注,维持量为5mg/kg 持续静脉滴注,直至患儿停止呼吸暂停1周,比较两组患儿的治疗有效率和呼吸暂停的发作持续时间、发作频次、症状消失时间。结果观察组总有效率高于对照组,两组比较差异有统计学意义(P <0.05);观察组患儿的呼吸暂停在治疗结束后的发作持续时间、发作频次、症状消失时间均少于对照组,两组比较差异有统计学意义(P <0.05),两组患儿在治疗过程中未见不良反应,且对心率血压影响无差异。结论枸橼酸咖啡因以10mg/kg 维持量治疗新生儿呼吸暂停疗效显著,有利于患儿早期康复。
目的:探討不同劑量枸櫞痠咖啡因治療新生兒呼吸暫停的臨床療效。方法選擇2013年1月~2014年7月本院收治的呼吸暫停新生兒82例作為研究對象,隨機分為兩組,每組41例,兩組均採用枸櫞痠咖啡因治療新生兒呼吸暫停,觀察組首次劑量為20mg/kg,靜脈滴註,維持量為10mg/kg 持續靜脈滴註,對照組按照傳統的劑量首次劑量為20mg/kg,靜脈滴註,維持量為5mg/kg 持續靜脈滴註,直至患兒停止呼吸暫停1週,比較兩組患兒的治療有效率和呼吸暫停的髮作持續時間、髮作頻次、癥狀消失時間。結果觀察組總有效率高于對照組,兩組比較差異有統計學意義(P <0.05);觀察組患兒的呼吸暫停在治療結束後的髮作持續時間、髮作頻次、癥狀消失時間均少于對照組,兩組比較差異有統計學意義(P <0.05),兩組患兒在治療過程中未見不良反應,且對心率血壓影響無差異。結論枸櫞痠咖啡因以10mg/kg 維持量治療新生兒呼吸暫停療效顯著,有利于患兒早期康複。
목적:탐토불동제량구연산가배인치료신생인호흡잠정적림상료효。방법선택2013년1월~2014년7월본원수치적호흡잠정신생인82례작위연구대상,수궤분위량조,매조41례,량조균채용구연산가배인치료신생인호흡잠정,관찰조수차제량위20mg/kg,정맥적주,유지량위10mg/kg 지속정맥적주,대조조안조전통적제량수차제량위20mg/kg,정맥적주,유지량위5mg/kg 지속정맥적주,직지환인정지호흡잠정1주,비교량조환인적치료유효솔화호흡잠정적발작지속시간、발작빈차、증상소실시간。결과관찰조총유효솔고우대조조,량조비교차이유통계학의의(P <0.05);관찰조환인적호흡잠정재치료결속후적발작지속시간、발작빈차、증상소실시간균소우대조조,량조비교차이유통계학의의(P <0.05),량조환인재치료과정중미견불량반응,차대심솔혈압영향무차이。결론구연산가배인이10mg/kg 유지량치료신생인호흡잠정료효현저,유리우환인조기강복。
Objective To evaluate the curative effect of different doses of caffeine citrate in the treatment of apnea neonatorum. Methods 82 patients with apnea neonatorum who were admitted to our hospital from January 2013 to July 2014 were selected as research subjects and were randomly allocated to the observation group and the control group,with 41 in each.Patients with apnea neonatorum in two groups were both received caffeine citrate.Patients in the observation group were received first dose of 20mg/kg by intravenous drip and maintenance dose of 10mg/kg by continuous infusion while patients in the control group were received first dose of 20mg/kg by intravenous drip and maintenance dose of 5mg/kg by continuous infusion until one week after the patients stopped apnea.Effective rate of treatment,episode duration of apnea,episode frequency and symptom disappearance time of the two groups were compared. Results Total effective rate in the observation group was higher than that in the control group and the difference was statistically significant(P < 0.05).Episode duration, episode frequency,symptom disappearance time of apnea after the treatment in the observation group were all less than those in the control group and the difference was statistically significant(P < 0.05).No adverse reaction appeared in the treatment and there was no difference in the effect on heart rate and blood pressure in two groups. Conclusion Maintenance dose of 10mg/kg of caffeine citrate in the treatment of apnea neonatorum has a significant curative effect and it is useful for patients' early rehabilitation.