CAJ | 학술논문

目的：研究丙种球蛋白联合阿司匹林对小儿川崎病的临床治疗效果及安全性，为临床治疗川崎病提供参考和借鉴。方法选择2012年1月~2014年7月我院收治的46例小儿川崎病患儿作为临床研究对象，随机分为两组。对照组患者23例，单纯使用阿司匹林治疗；实验组患者23例给予阿司匹林联合丙种球蛋白治疗，对比观察两组患儿的治疗效果和症状改善时间。结果实验组患儿发热时间短、黏膜充血时间更短、颈淋巴结消散快，患儿手足肿胀时间短，与对照组比较差异有统计学意义（P ＜0.05）；对照组患儿发生冠状动脉扩张比例较高，与实验组比较差异有统计学意义（P ＜0.05）。结论使用丙种球蛋白联合阿司匹林对小儿川崎病治疗的效果较好，有助于患儿早期康复，降低冠状动脉扩张率，值得应用。
목적：연구병충구단백연합아사필림대소인천기병적림상치료효과급안전성，위림상치료천기병제공삼고화차감。방법선택2012년1월~2014년7월아원수치적46례소인천기병환인작위림상연구대상，수궤분위량조。대조조환자23례，단순사용아사필림치료；실험조환자23례급여아사필림연합병충구단백치료，대비관찰량조환인적치료효과화증상개선시간。결과실험조환인발열시간단、점막충혈시간경단、경림파결소산쾌，환인수족종창시간단，여대조조비교차이유통계학의의（P ＜0.05）；대조조환인발생관상동맥확장비례교고，여실험조비교차이유통계학의의（P ＜0.05）。결론사용병충구단백연합아사필림대소인천기병치료적효과교호，유조우환인조기강복，강저관상동맥확장솔，치득응용。
Objective To clinical efficacy and safety of gamma globulin combined aspirin on children with Kawasaki disease,provide reference for the clinical treatment of Kawasaki disease. Methods 46 cases of children with Kawasaki disease in our hospital from January 2012 to July 2014 were selected as a clinical study,were randomly divided into two groups.23 patients in the control group only received aspirin therapy;the experimental group with 23 patients further received gamma globulin therapy,treatment effects and symptoms time between the two groups were compared. Results Children with a short fever time in the experimental group,mucosal congestion was shorter,neck lymph nodes dissipate was quicker,the time of children with hand,foot swelling was shorter,compared with the control group with significant difference(P < 0.05);the children in the control group occurred a higher proportion of coronary dilatation,with significant differences between the two groups(P < 0.05),the difference was statistically significant. Conclusion The use of gamma globulin and aspirin therapy in children with Kawasaki disease is better,help children with early rehabilitation,reduce the rate of coronary artery,and it is worthy of applications.