医药导报
醫藥導報
의약도보
HERALD OF MEDICINE
2015年
6期
795-798
,共4页
应景艳%徐爱仁%戎建辉%马卫成%何文跃
應景豔%徐愛仁%戎建輝%馬衛成%何文躍
응경염%서애인%융건휘%마위성%하문약
二氧化钛(TiO2 )%药物载体%释放,pH 敏感%近红外
二氧化鈦(TiO2 )%藥物載體%釋放,pH 敏感%近紅外
이양화태(TiO2 )%약물재체%석방,pH 민감%근홍외
Titanium dioxide (TiO2 )%Drug carrier%Release,pH sensitivity%Near-infrared light
目的：制备具有近红外荧光的纳米二氧化钛(TiO2),并考察纳米粒的载药及体外释放性能。方法通过水热法合成掺杂钐的 TiO2(Sm-TiO2),采用透射电镜(TEM)对其进行表征,测定其荧光光谱,并考察对多柔比星(DOX)的载药量及体外释放曲线。结果所制备的纳米粒分散均匀,外观呈梭状,长度100~200 nm,发射波长640~670 nm,在水中的载药量达11.5%,体外释放具有 pH 敏感性。结论所制备 Sm-TiO2有良好的近红外荧光发光效果、较高的载药量及可控的体外释放,可以作为新型药物载体深入研究。
目的：製備具有近紅外熒光的納米二氧化鈦(TiO2),併攷察納米粒的載藥及體外釋放性能。方法通過水熱法閤成摻雜釤的 TiO2(Sm-TiO2),採用透射電鏡(TEM)對其進行錶徵,測定其熒光光譜,併攷察對多柔比星(DOX)的載藥量及體外釋放麯線。結果所製備的納米粒分散均勻,外觀呈梭狀,長度100~200 nm,髮射波長640~670 nm,在水中的載藥量達11.5%,體外釋放具有 pH 敏感性。結論所製備 Sm-TiO2有良好的近紅外熒光髮光效果、較高的載藥量及可控的體外釋放,可以作為新型藥物載體深入研究。
목적：제비구유근홍외형광적납미이양화태(TiO2),병고찰납미립적재약급체외석방성능。방법통과수열법합성참잡삼적 TiO2(Sm-TiO2),채용투사전경(TEM)대기진행표정,측정기형광광보,병고찰대다유비성(DOX)적재약량급체외석방곡선。결과소제비적납미립분산균균,외관정사상,장도100~200 nm,발사파장640~670 nm,재수중적재약량체11.5%,체외석방구유 pH 민감성。결론소제비 Sm-TiO2유량호적근홍외형광발광효과、교고적재약량급가공적체외석방,가이작위신형약물재체심입연구。
Objective To prepare titanium dioxide (TiO2 ) nanoparticles with good near-infrared light and study the loading and release of doxorubicin. Methods The Sm doped TiO2 nanoparticles (Sm-TiO2 ) were synthesized using a modified solvothermal reaction and then observed with transmission electron microscope. The fluorescence spectrum, doxorubicin loading capacity and release profile were also determined. Results The obtained Sm-TiO2 nanoparticles with the length from 100-200 nm were fusiform and well dispersed. The emission wavelength was 640-670 nm. The drug loading capacity in water was 11. 5% . DOX in vitro was pH sensitive to release. Conclusion Sm-TiO2 nanoparticles have good near-infrared light, high drug loading capacity and controllable drug release are obtained and should be studied further more as a novel carrier.
