医药导报
醫藥導報
의약도보
HERALD OF MEDICINE
2015年
6期
730-732
,共3页
廖乙媚%刘滔滔%程道海%陆华
廖乙媚%劉滔滔%程道海%陸華
료을미%류도도%정도해%륙화
胱抑素 C%血肌酐%万古霉素%Bayesian 反馈法
胱抑素 C%血肌酐%萬古黴素%Bayesian 反饋法
광억소 C%혈기항%만고매소%Bayesian 반궤법
Cystatin C%Serum creatinine%Vancomycin%Bayesian forecasting method
目的:探讨应用血清胱抑素 C(Cys C)作为肾功能指标预测万古霉素血药谷浓度的临床效用。方法收集81例接受万古霉素治疗的住院患者万古霉素血药谷浓度(Cmea )、血清肌酐(Scr)浓度、Cys C 浓度,根据 Scr 或 Cys C浓度结合 Bayesian 反馈法通过 NONMEM 软件预测万古霉素血药谷浓度(Cpre ),比较预测 Cpre与实测 Cmea的相关性和差别。结果患者基于 Scr 或 Cys C 预测的 Cpre与实测 Cmea间均存在相关性(r =0.678,P<0.01;r =0.727,P<0.01);基于Scr 的平均预测误差(ME)、平均绝对误差(MAE)、均方根误差(RMSE)分别为-5.79,6.86,9.86μg·mL-1,基于 Cys C 的ME、MAE、RMSE 则分别为-0.82,5.42,7.74μg·mL-1。结论 Cys C 是一项良好的肾功能指标,可用于预测万古霉素血药浓度,指导临床用药。
目的:探討應用血清胱抑素 C(Cys C)作為腎功能指標預測萬古黴素血藥穀濃度的臨床效用。方法收集81例接受萬古黴素治療的住院患者萬古黴素血藥穀濃度(Cmea )、血清肌酐(Scr)濃度、Cys C 濃度,根據 Scr 或 Cys C濃度結閤 Bayesian 反饋法通過 NONMEM 軟件預測萬古黴素血藥穀濃度(Cpre ),比較預測 Cpre與實測 Cmea的相關性和差彆。結果患者基于 Scr 或 Cys C 預測的 Cpre與實測 Cmea間均存在相關性(r =0.678,P<0.01;r =0.727,P<0.01);基于Scr 的平均預測誤差(ME)、平均絕對誤差(MAE)、均方根誤差(RMSE)分彆為-5.79,6.86,9.86μg·mL-1,基于 Cys C 的ME、MAE、RMSE 則分彆為-0.82,5.42,7.74μg·mL-1。結論 Cys C 是一項良好的腎功能指標,可用于預測萬古黴素血藥濃度,指導臨床用藥。
목적:탐토응용혈청광억소 C(Cys C)작위신공능지표예측만고매소혈약곡농도적림상효용。방법수집81례접수만고매소치료적주원환자만고매소혈약곡농도(Cmea )、혈청기항(Scr)농도、Cys C 농도,근거 Scr 혹 Cys C농도결합 Bayesian 반궤법통과 NONMEM 연건예측만고매소혈약곡농도(Cpre ),비교예측 Cpre여실측 Cmea적상관성화차별。결과환자기우 Scr 혹 Cys C 예측적 Cpre여실측 Cmea간균존재상관성(r =0.678,P<0.01;r =0.727,P<0.01);기우Scr 적평균예측오차(ME)、평균절대오차(MAE)、균방근오차(RMSE)분별위-5.79,6.86,9.86μg·mL-1,기우 Cys C 적ME、MAE、RMSE 칙분별위-0.82,5.42,7.74μg·mL-1。결론 Cys C 시일항량호적신공능지표,가용우예측만고매소혈약농도,지도림상용약。
Objective To investigate the clinical efficiency of serum cystatin C as a marker of renal function to predict serum trough concentrations of vancomycin. Methods Data on trough concentrations of vancomycin(Cmea ),serum creatinine (Scr)concentrations,cystatin C( Cys C) concentrations were collected from 81 hospitalized patients who received vancomycin therapy. Predicted vancomycin trough concentrations(Cpre )were calculated based on Scr or Cys C concentrations associating with Bayesian forecasting method through NONMEM software. Finally,the correlations and distinctions between Cpre and Cmea were comparatively analyzed. Results There were both correlation between Cpre and Cmea in relation to Scr or Cys C(r = 0. 678,P<0. 01;r=0. 727,P<0. 01). Besides,the errors of mean predictive error(ME),mean absolute error(MAE)and root-mean-square error(RMSE)for Scr was - 5. 79,6. 86,9. 86 μg · mL-1 , respectively, where as the errors for Cys C was - 0. 82,5. 42, 7. 74 μg·mL-1 ,respectively. Conclusion Cystatin C is a good marker of renal function available for predicting serum vancomycin concentrations.