CAJ | 학술논문

目的：研究薏苡茎水提取物对荷瘤小鼠的抑瘤作用及对免疫器官的影响。方法以肝癌H22荷瘤小鼠作为实验动物模型，将实验小鼠随机分成7组，模型组、环磷酰胺组、5个剂量实验组，分别给予0.9％氯化钠、环磷酰胺（0.02 g? kg-1）、薏苡茎水提取物（2，4，6，8，10 g? kg-1）灌胃给药。连续9 d后，颈椎脱臼处死，称重并剖离肿瘤、肝、胸腺、脾，计算体质量、抑瘤率及肝、胸腺、脾指数。结果与模型组比较，薏苡茎水提取物对肝癌H22具有明显的抑制作用（ P＜0.05），其对肝指数、体重增长也有明显的影响（ P＜0.05）。但其对荷瘤小鼠的胸腺、脾指数无明显影响。结论薏苡茎水提取物具有抗肿瘤作用。
목적：연구의이경수제취물대하류소서적억류작용급대면역기관적영향。방법이간암H22하류소서작위실험동물모형，장실험소서수궤분성7조，모형조、배린선알조、5개제량실험조，분별급여0.9％록화납、배린선알（0.02 g? kg-1）、의이경수제취물（2，4，6，8，10 g? kg-1）관위급약。련속9 d후，경추탈구처사，칭중병부리종류、간、흉선、비，계산체질량、억류솔급간、흉선、비지수。결과여모형조비교，의이경수제취물대간암H22구유명현적억제작용（ P＜0.05），기대간지수、체중증장야유명현적영향（ P＜0.05）。단기대하류소서적흉선、비지수무명현영향。결론의이경수제취물구유항종류작용。
Objective To study the tumor inhibitory effects and an in-fluence on immune organs of the water extract from stem of Coix Lachry-ma-jobi L.(WESCLL) in mice with liver cancer H22.Methods The experimental subjects were using mice with liver cancer H 22.The mice are randomly divided into 7 groups and were fed 0.9%sodium chloride , cyclophosphamide (0.02 g? kg -1 ), WESCLL(2,4,6,8,10 g? kg -1 ) by oral gavages.After 9 days′administration, the mice were killed. Their subcutaneous sarcoma ,liver,thymus and spleen were separated and weighted.Then the tumor inhibiting rates and liver , thymus and spleen index were calculated.Results The WESCLL has obvious effects on re-straining the liver cancer H22.There was significant difference compared with model group (P<0.05).The effect of WESCLL is more noticeable on liver index and weigh′s increase of the mice ( P<0.05 ) .There was not significant difference on thymus and spleen indexes compared with model group ( P<0.05 ) .Conclusion WESCLL have distinct effect on anti-tumor.