中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
10期
176-178
,共3页
血小板活化%P-选择素%COPD%整合素%临床研究
血小闆活化%P-選擇素%COPD%整閤素%臨床研究
혈소판활화%P-선택소%COPD%정합소%림상연구
Platelet activation%P-selectin%COPD%Integrin%Clinical research
目的：探析慢性阻塞性肺病（COPD）发病中 P-选择素及整合素相关蛋白 CD47的作用。方法入选2013年5月～2014年5月我院 COPD 患者82例为实验组，同期入选体检健康者82例为研究对照，检测所有研究对象外周血浆的 P-选择素及整合素相关蛋白 CD47水平，比较两组研究对照外周血浆中的 P-选择素及整合素相关蛋白 CD47水平；比较 COPD 急性加重期及稳定期患者的外周血浆中的 P-选择素及整合素相关蛋白 CD47水平。结果实验组外周血浆中的 P-选择素及整合素相关蛋白 CD47水平显著高于对照组，差异有统计学意义（P ＜0.05），两组血小板计数无统计学意义（P ＞0.05）；COPD 急性加重期血小板的P-选择素及整合素相关蛋白 CD47水平显著高于 COPD 稳定期，差异有统计学意义（P ＜0.05）。结论 P-选择素和整合素相关蛋白 CD47为判定 COPD 病情严重程度及血小板活化程度的敏感指标。
目的：探析慢性阻塞性肺病（COPD）髮病中 P-選擇素及整閤素相關蛋白 CD47的作用。方法入選2013年5月～2014年5月我院 COPD 患者82例為實驗組，同期入選體檢健康者82例為研究對照，檢測所有研究對象外週血漿的 P-選擇素及整閤素相關蛋白 CD47水平，比較兩組研究對照外週血漿中的 P-選擇素及整閤素相關蛋白 CD47水平；比較 COPD 急性加重期及穩定期患者的外週血漿中的 P-選擇素及整閤素相關蛋白 CD47水平。結果實驗組外週血漿中的 P-選擇素及整閤素相關蛋白 CD47水平顯著高于對照組，差異有統計學意義（P ＜0.05），兩組血小闆計數無統計學意義（P ＞0.05）；COPD 急性加重期血小闆的P-選擇素及整閤素相關蛋白 CD47水平顯著高于 COPD 穩定期，差異有統計學意義（P ＜0.05）。結論 P-選擇素和整閤素相關蛋白 CD47為判定 COPD 病情嚴重程度及血小闆活化程度的敏感指標。
목적：탐석만성조새성폐병（COPD）발병중 P-선택소급정합소상관단백 CD47적작용。방법입선2013년5월～2014년5월아원 COPD 환자82례위실험조，동기입선체검건강자82례위연구대조，검측소유연구대상외주혈장적 P-선택소급정합소상관단백 CD47수평，비교량조연구대조외주혈장중적 P-선택소급정합소상관단백 CD47수평；비교 COPD 급성가중기급은정기환자적외주혈장중적 P-선택소급정합소상관단백 CD47수평。결과실험조외주혈장중적 P-선택소급정합소상관단백 CD47수평현저고우대조조，차이유통계학의의（P ＜0.05），량조혈소판계수무통계학의의（P ＞0.05）；COPD 급성가중기혈소판적P-선택소급정합소상관단백 CD47수평현저고우 COPD 은정기，차이유통계학의의（P ＜0.05）。결론 P-선택소화정합소상관단백 CD47위판정 COPD 병정엄중정도급혈소판활화정도적민감지표。
Objective To explore the role of P-select elements and integrin-associated protein CD47 in the pathogenesis of chronic obstructive pulmonary disease (COPD). Methods 82 patients with COPD in our hospital from May 2013 to May 2014 were chosen as the experimental group.82 cases of healthy subjects the same period were chosen as the control group.The P- selectin and integrin-associated protein CD47 levels of peripheral plasma of the research subjects were taken for detection.The P- selectin and integrin-associated protein CD47 levels of peripheral plasma of the research subjects were compared.The P-selectin and integrin-associated protein CD47 levels of peripheral plasma of the research subjects in the acute exacerbation and stable of COPD were compared. Results The P- selectin and integrin-associated protein CD47 levels of peripheral plasma in the experimental group were significantly higher than the control group, and the differences were with statistical significance(P < 0.05),and the platelet count in both groups was without statistical difference(P > 0.05).The platelet P- selectin and integrin-associated protein CD47 levels in the acute exacerbation of COPD were significantly higher than in stable COPD,and the differences were with statistical significance(P < 0.05). Conclusion P-selectin and integrin-associated protein CD47 is a sensitive indicator of the judgment severity of COPD disease and extent of platelet activation.
