CAJ | 학술논문

中东呼吸综合征（MERS）是由新型冠状病毒MERS-CoV感染引起的传染病，2012年在沙特被首次发现，疫情主要集中在中东地区，在欧洲、非洲、北美洲和亚洲也有少量病例报告，近期韩国连续报告数十病例，并且1例经香港输入中国大陆地区。目前，临床上尚无针对MERS-CoV的特异性抗病毒药物和治疗方法，主要是对症治疗，在防止并发症的同时实施有效的呼吸、循环支持和肾功能保护。本文对文献报道的潜在临床治疗方法，抗MERS-CoV的潜在药物靶点和小分子治疗药物的研究进展进行综述。
중동호흡종합정（MERS）시유신형관상병독MERS-CoV감염인기적전염병，2012년재사특피수차발현，역정주요집중재중동지구，재구주、비주、북미주화아주야유소량병례보고，근기한국련속보고수십병례，병차1례경향항수입중국대륙지구。목전，림상상상무침대MERS-CoV적특이성항병독약물화치료방법，주요시대증치료，재방지병발증적동시실시유효적호흡、순배지지화신공능보호。본문대문헌보도적잠재림상치료방법，항MERS-CoV적잠재약물파점화소분자치료약물적연구진전진행종술。
Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by the newly identified MERS-CoV, which was first discovered in Saudi Arabia in 2012. Although most cases of MERS have occurred in Middle East, cases also have been reported in Europe, the USA and Asia in people who travelled from the Middle East or their contacts. The most recent outbreak was in South Korea with over dozens of cases, wherein, one case imported into mainland China via Hong Kong. No specific drug treatment exists for MERS now. Supportive treatment, aiming to prevent complications, supporting the function of respiratory, circulatory and renal, was the mainstay of management. In this paper, the reported clinical treatment, the research progress of potential targets and small molecule drugs for anti MERS-CoV were reviewed.