CAJ | 학술논문

目的：探讨睡眠呼吸暂停综合征（SAS）与血管性认知功能障碍（VCI）之间的相关性。方法48例SAS 合并 VCI 患者，根据睡眠呼吸障碍的严重程度分为三组（n=16）：轻度障碍组、中度障碍组和重度障碍组；并设立健康对照组（n=16）。通过分析各组的低通气指数（AHI）、最低血氧饱和度（LSaO2）与简易智能精神状态检查量表(MMSE)评分之间的关系，推测 SAS 与 VCI 之间的相关性。结果轻度、中度、重度障碍组的患者 AHI 显著高于对照组（t=9.150，P=0.000；t=13.361，P=0.000；t=19.566，P=0.000），轻度、中度、重度障碍组的患者 LSaO2显著低于对照组（t=6.312，P=0.000；t=11.063，P=0.000；t=11.132，P=0.000）,而 MMSE显著低于对照组（t=3.716，P=0.001；t=6.816，P=0.000；t=6.936，P=0.000）；AHI、LSaO2分别于与 MMSE 评分均呈现正负相关性（P ＜0.05）。结论 SAS 的严重程度与 VCI 呈正相关。
목적：탐토수면호흡잠정종합정（SAS）여혈관성인지공능장애（VCI）지간적상관성。방법48례SAS 합병 VCI 환자，근거수면호흡장애적엄중정도분위삼조（n=16）：경도장애조、중도장애조화중도장애조；병설립건강대조조（n=16）。통과분석각조적저통기지수（AHI）、최저혈양포화도（LSaO2）여간역지능정신상태검사량표(MMSE)평분지간적관계，추측 SAS 여 VCI 지간적상관성。결과경도、중도、중도장애조적환자 AHI 현저고우대조조（t=9.150，P=0.000；t=13.361，P=0.000；t=19.566，P=0.000），경도、중도、중도장애조적환자 LSaO2현저저우대조조（t=6.312，P=0.000；t=11.063，P=0.000；t=11.132，P=0.000）,이 MMSE현저저우대조조（t=3.716，P=0.001；t=6.816，P=0.000；t=6.936，P=0.000）；AHI、LSaO2분별우여 MMSE 평분균정현정부상관성（P ＜0.05）。결론 SAS 적엄중정도여 VCI 정정상관。
Objective To investigate the Correlation between SAS and VCI. Methods 48 patients with SAS and VCI were selected. According to the severity of sleep apnea, all patients can be divided into three groups (n=16):mild-obstacle group, moderate-obstacle group and severe -obstacle group. Meanwhile, a control group (n=16) was set up.AHI and LSaO2 and MMSE of 3 groups were observed to evaluate relationship between SAS and VCI. Results The AHI of mild-obstacle group, moderate-obstacle group and severe -obstacle group was higher than that of control group(P < 0.05).The LSaO2 and the MMSE of mild-obstacle group, moderate-obstacle group and severe -obstacle group was lower than that of control group(P < 0.05). The AHI and the LSaO2 and the score of MMSE have carried out a positive and negative correlation respectively(P < 0.05). Conclusion The severity of the SAS and VCI are positively correlated.