CAJ | 학술논문

目的：探讨微创保胆取石术联合牛磺熊去氧胆酸治疗胆囊结石的疗效，并与腹腔镜胆囊切除术疗效对比。方法选取2011年4月～2013年4月我院治疗的胆囊结石患者80例，随机分为研究组和对照组各40例，研究组采用微创保胆取石术联合牛磺熊去氧胆酸治疗。对照组给予常规腹腔镜胆囊切除手术治疗。观察两组患者手术时间、术中出血量、术后住院时间及饮食恢复时间；手术前与术后1年研究组患者症状、胆囊壁厚度、胆囊收缩功能及复发情况。结果研究组术中出血量明显少于对照组，术后饮食恢复时间明显缩短（P ＜0.05）。随访1年后，研究组症状发生率明显降低，胆囊壁厚度明显变薄，胆囊收缩功能明显改善（P ＜0.05）；且胆囊结石复发率仅为5.0%。结论微创保胆取石术联合牛磺熊去氧胆酸治疗胆囊结石患者疗效优于腹腔镜胆囊切除术，术后能明显改善胆囊收缩功能，降低复发率。
목적：탐토미창보담취석술연합우광웅거양담산치료담낭결석적료효，병여복강경담낭절제술료효대비。방법선취2011년4월～2013년4월아원치료적담낭결석환자80례，수궤분위연구조화대조조각40례，연구조채용미창보담취석술연합우광웅거양담산치료。대조조급여상규복강경담낭절제수술치료。관찰량조환자수술시간、술중출혈량、술후주원시간급음식회복시간；수술전여술후1년연구조환자증상、담낭벽후도、담낭수축공능급복발정황。결과연구조술중출혈량명현소우대조조，술후음식회복시간명현축단（P ＜0.05）。수방1년후，연구조증상발생솔명현강저，담낭벽후도명현변박，담낭수축공능명현개선（P ＜0.05）；차담낭결석복발솔부위5.0%。결론미창보담취석술연합우광웅거양담산치료담낭결석환자료효우우복강경담낭절제술，술후능명현개선담낭수축공능，강저복발솔。
Objective To investigate the curative effect of minimally invasive cholecystolithotomy with gallbladder reservation combined tauroursodeoxycholic acid in the treatment of cholecystolithiasis,and contrast with laparoscopic cholecystectomy. Methods 80 patients with cholecystolithiasis from 2011 April to 2013 April in our hospital were randomly divided into study group and control group with 40 cases in each group,the study group were treated with minimally invasive cholecystolithotomy with gallbladder reservation combined tauroursodeoxycholic acid treatment. The control group was given conventional laparoscopic cholecystectomy treatment.The operation time,intraoperative bleeding volume,postoperative hospitalization time and time to resume diet of patients in two groups and symptoms,gallbladder wall thickness,gallbladder contraction function and recurrence rate of patients in study group before operation and 1 year after operation were observed. Results The intraoperative bleeding volume of the study group was significantly less than the control group,postoperative time to resume diet was significantly shorter(P <0.05). After one year of follow-up,the incidence of symptoms of the study group was significantly lower,gallbladder wall thickness was thinned,gallbladder contraction function improved significantly(P < 0.05);and the recurrence rate of cholecystolithiasis was only 5.0%. Conclusion The effect of minimally invasive cholecystolithotomy with gallbladder reservation combined tauroursodeoxycholic acid in the treatment of cholecystolithiasis is better than laparoscopic cholecystectomy,and it can obviously improve the gallbladder contraction function,reduce the recurrence rate.