CAJ | 학술논문

肝X受体是配体激活的核受体转录因子超家族成员，在脂质代谢中起关键的调控作用。在过去的10年中，大量研究表明，肝X受体通过激活或抑制其靶基因，参与一系列代谢和炎症反应的生理过程，从而与心血管疾病紧密联系。肝X受体在对抗动脉粥样硬化发展过程中的作用日益突出，为此本文就在动脉粥样硬化发病机制中肝X受体信号通路所涉及的靶点进行综述。
간X수체시배체격활적핵수체전록인자초가족성원，재지질대사중기관건적조공작용。재과거적10년중，대량연구표명，간X수체통과격활혹억제기파기인，삼여일계렬대사화염증반응적생리과정，종이여심혈관질병긴밀련계。간X수체재대항동맥죽양경화발전과정중적작용일익돌출，위차본문취재동맥죽양경화발병궤제중간X수체신호통로소섭급적파점진행종술。
Liver X receptor is a ligand -activated transcription factor of nuclear receptor super family .It played a key role in the regulation of lipid metabolism.In the past decade , numerous studies show that liver X receptor are involved in a series of physiological processes such as meta-bolism and inflammation by activating or inhibiting its target genes that are so closely linked with cardiovascular diseases .In recent years, a large number of studies have shown that liver X receptor are increasingly prominent in fighting against atherosclerosis . In this paper , we will review the targets of the LXR pathways on the pathogenesis of atherosclerosis.