CAJ | 학술논문

目的：观察铝碳酸镁联合奥美拉唑对胃溃疡合并胃出血的疗效。方法选取我院消化科收治的胃溃疡合并胃出血患者76例，随机分为两组，其中对照组38例，予奥美拉唑常规治疗，10mg 口服，3次/d，4周作为1个疗程，连续治疗2个疗程；实验组患者38例，于对照组基础上加用铝碳酸镁，0.5g 口服，3次/d，4周为1个疗程，治疗2个疗程。治疗后对比治疗前后患者临床症状评分、不良反应、复发率及临床疗效。结果治疗后两组患者临床症状评分均有所改善，与对照组比较，实验组临床评分下降明显，差异具有统计学意义（P ＜0.05）；治疗后实验组不良反应发生率及胃出血复发明显少于对照组，差异有统计学意义（P ＜0.05）；实验组临床疗效明显优于对照组，差异有统计学意义（P ＜0.05）。结论铝碳酸镁联合奥美拉唑胃溃疡合并胃出血较单独使用奥美拉唑具有较高疗效，对临床具有指导意义，值得临床推广。
목적：관찰려탄산미연합오미랍서대위궤양합병위출혈적료효。방법선취아원소화과수치적위궤양합병위출혈환자76례，수궤분위량조，기중대조조38례，여오미랍서상규치료，10mg 구복，3차/d，4주작위1개료정，련속치료2개료정；실험조환자38례，우대조조기출상가용려탄산미，0.5g 구복，3차/d，4주위1개료정，치료2개료정。치료후대비치료전후환자림상증상평분、불량반응、복발솔급림상료효。결과치료후량조환자림상증상평분균유소개선，여대조조비교，실험조림상평분하강명현，차이구유통계학의의（P ＜0.05）；치료후실험조불량반응발생솔급위출혈복발명현소우대조조，차이유통계학의의（P ＜0.05）；실험조림상료효명현우우대조조，차이유통계학의의（P ＜0.05）。결론려탄산미연합오미랍서위궤양합병위출혈교단독사용오미랍서구유교고료효，대림상구유지도의의，치득림상추엄。
Objective To evaluate the effect of Hydrotalcid combined with omeprazole on gastric ulcerwith gastric hemorrhage. Methods 76 cases of gastric ulcer with bleeding in the stomach were selected of digestive department of our hospital,were randomly divided into two groups,38 cases in the control group,omeprazole conventional treatment,oral 10mg,3 times a day,4 weeks as a course of treatment,continuoustreatment of two courses;38 cases of patients in the experimental group,in the control group based on the use of hydrotalcite,oral 0.5g,3 times a day,4 weeks as a course of treatment two a course of treatment.After the treatment,compared the clinical symptoms before and after treatment score,adverse reaction,recurrence rate and clinical efficacy. Results After the treatment of two groups of patients with clinical symptom score were improved,compared with the control group,the experimental group clinical scoredecreased significantly,with significant difference(P < 0.05);and the rate ofrecurrence of bleeding in the stomach compared the adverse reaction of two groups were compared after treatment,the experimental group of adverse reaction incidence and recurrence of gastric bleeding obvious less than the control group,the difference was statistically significant(P < 0.05);the clinicalcurative effect of experimental group was significantly better than the control group,the difference was statistically significant(P< 0.05). Conclusion Omeprazole combined with hydrotalcite have a high curative effect of gastric bleeding stomach ulcer patients,and it is worth the clinical promotion.