CAJ | 학술논문

目的：了解血液病患者尿路感染病原谱特点及耐药性，为临床合理选用抗菌药物治疗血液病患者尿路感染提供参考。方法对医院血液科2011年1月至2013年12月血液病患者尿培养标本分离的病原性细菌分布及耐药性进行分析，头孢噻肟／克拉维酸双纸片表型法筛选产超广谱β‐内酰胺酶（ESBLs）菌。结果共分离595株病原菌，426株革兰阴性菌，占71．6％。大肠埃希菌是居首位的病原菌，占33．4％。大肠埃希菌和肺炎克雷伯菌中产超广谱β‐内酰胺酶（ESBLs）菌的检出率分别为83．9％、82．8％。粪肠球菌与屎肠球菌检出率分别为7．9％和17．8％。结论血液病患者尿路感染主要病原菌以革兰阴性菌为主，表现为尿路感染产 ESBLs 肠杆菌科菌非常严重，应引起重视，根据敏感性试验选择合理抗菌药治疗尿路感染。
목적：료해혈액병환자뇨로감염병원보특점급내약성，위림상합리선용항균약물치료혈액병환자뇨로감염제공삼고。방법대의원혈액과2011년1월지2013년12월혈액병환자뇨배양표본분리적병원성세균분포급내약성진행분석，두포새우／극랍유산쌍지편표형법사선산초엄보β‐내선알매（ESBLs）균。결과공분리595주병원균，426주혁란음성균，점71．6％。대장애희균시거수위적병원균，점33．4％。대장애희균화폐염극뢰백균중산초엄보β‐내선알매（ESBLs）균적검출솔분별위83．9％、82．8％。분장구균여시장구균검출솔분별위7．9％화17．8％。결론혈액병환자뇨로감염주요병원균이혁란음성균위주，표현위뇨로감염산 ESBLs 장간균과균비상엄중，응인기중시，근거민감성시험선택합리항균약치료뇨로감염。
Objective To investigate the distribution and antimicrobial resistance of pathogenic bacteria from hematological pa‐tients with urinary tract infections(UTI) so as to provide laboratory evidence for rationally selecting antibiotics in clinical practice . Methods The distribution and antimicrobial resistance of pathogenic bacteria from hematological patients with UTI were analyzed from January 2011 to December 2013 .Results A total of 595 strains pathogens were isolated ,including 426(71 .6% ) strains of gram‐negative bacteria ,Escherichia coli(E .coli) was the most common pathogenic bacteria ,accounting for 33 .4% ,the detection rates of producing extended spectrum lactamase (ESBLs)of E .coli and Klebisella pneumoniae were 83 .9% and 82 .8% respective‐ly .And the detection rates of Enterococcus faecalis (E .faecalis) ,Enterococcus faecium (E .Faecium) were 7 .9% and 17 .8% re‐spectively .Conclusion In the pathogenic bacteria from hematological patients with UTI ,the gram‐negative bacteria is the predomi‐nant pathogens ,The performance for the urinary tract infection of Enterobacteriaceae producing ESBLs are very serious ,it is neces‐sary to choose antibiotics based on the antimicrobial susceptibility testing .